Shaikh Alisha, Wesner Austin A, Abuhattab Mohanad, Kutty Raman G, Premnath Priyatha
Department of Biomedical Engineering, University of Wisconsin-Milwaukee, College of Engineering and Applied Sciences, 3200 N Cramer St, Milwaukee, WI, 53211, USA.
Department of Internal Medicine, White River Health System, Batesville, AR, USA.
Cell Biosci. 2023 Feb 21;13(1):35. doi: 10.1186/s13578-023-00988-7.
Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in differentiation, apoptosis, senescence, and other cell processes. Emerging evidence has demonstrated a role for cell cycle regulators in bone healing/development cascade. We demonstrated that deletion of p21, a cell cycle regulator acting at the G1/S transition enhanced bone repair capacity after a burr-hole injury in the proximal tibia of mice. Similarly, another study has shown that inhibition of p27 can increase bone mineral density and bone formation. Here, we provide a concise review of cell cycle regulators that influence cells like osteoblasts, osteoclasts, and chondrocytes, during development and/or healing of bone. It is imperative to understand the regulatory processes that govern cell cycle during bone healing and development as this will pave the way to develop novel therapies to improve bone healing after injury in instances of aged or osteoporotic fractures.
细胞周期调节因子作为抑制剂或激活剂来预防癌症发生。也已证实它们在分化、凋亡、衰老及其他细胞过程中可发挥积极作用。新出现的证据表明细胞周期调节因子在骨愈合/发育级联反应中发挥作用。我们证明，敲除在G1/S期转换起作用的细胞周期调节因子p21可增强小鼠胫骨近端钻孔损伤后的骨修复能力。同样，另一项研究表明，抑制p27可增加骨密度和骨形成。在此，我们简要综述在骨发育和/或愈合过程中影响成骨细胞、破骨细胞和软骨细胞等细胞的细胞周期调节因子。了解骨愈合和发育过程中调控细胞周期的过程至关重要，因为这将为开发新疗法以改善老年或骨质疏松性骨折损伤后的骨愈合铺平道路。
