International Center for Child Health and Development (ICHAD), Brown School Washington University, St. Louis, Missouri, USA.
J Adolesc. 2023 Jun;95(4):834-843. doi: 10.1002/jad.12157. Epub 2023 Feb 22.
This study examined the mechanisms through which family support affects self-reported adherence to antiretroviral therapy among adolescents perinatally infected with HIV in Uganda.
Longitudinal data from 702 adolescent boys and girls (10-16 years) were analyzed. Structural equation models were conducted to assess the direct, indirect, and total effects of family support on adherence.
Results showed a significant indirect effect of family support on adherence (β = .112, 95% confidence interval [CI]: 0.052-0.173, p < .001). Specific indirect effects of family support through saving attitudes (β = .058, 95% CI: 0.008-0.108, p = .024), and communication with the guardian (β = .056, 95% CI: 0.012-0.100), p = .013), as well as the total effect of family support on adherence (β = .146 (95% CI: 0.032-0.259, p = .012), were statistically significant. Mediation contributed 76.7% of the total effects.
Findings support strategies to help promote family support and strengthen open communication between adolescents living with HIV and their caregivers.
本研究探讨了家庭支持通过何种机制影响乌干达 HIV 围生期感染的青少年自我报告的抗逆转录病毒治疗依从性。
对 702 名青少年男孩和女孩（10-16 岁）进行了纵向数据分析。采用结构方程模型评估家庭支持对依从性的直接、间接和总效应。
结果显示，家庭支持对依从性有显著的间接影响（β=0.112，95%置信区间 [CI]：0.052-0.173，p<0.001）。家庭支持通过节约态度（β=0.058，95%CI：0.008-0.108，p=0.024）和与监护人沟通（β=0.056，95%CI：0.012-0.100，p=0.013）对依从性的特定间接影响，以及家庭支持对依从性的总效应（β=0.146（95%CI：0.032-0.259，p=0.012）均具有统计学意义。中介作用贡献了总效应的 76.7%。
研究结果支持采取策略，以帮助促进家庭支持，并加强 HIV 感染者青少年与其照顾者之间的开放沟通。
