Wang Weihong, Kim Seungjin, Vu Thi Hanh Nguyen, Quach Ngoc Tung, Oh Eunseok, Park Kyu-Hyung, Park Chanyoon, Cho Youbin, Jang Hyeseon, Roh Eun, Lee JunI, Kang Eunmo, Han SongJoo, Phi Quyet-Tien, Kang Heonjoong
Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
Research Institute of Oceanography, Seoul National University, NS-80, Seoul 08826, Korea.
J Nat Prod. 2023 Apr 28;86(4):751-758. doi: 10.1021/acs.jnatprod.2c00902. Epub 2023 Feb 22.
A chemical investigation of the endophytic sp. HBQ95, associated with the medicinal plant Presl, enabled the discovery of four new piperazic acid-bearing cyclodepsipeptides, lydiamycins E-H (-), and one known compound (lydiamycin A). Their chemical structures, including absolute configurations, were defined by a combination of spectroscopic analyses and multiple chemical manipulations. Lydiamycins F-H (-) and A () exhibited antimetastatic activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.
对与药用植物普雷斯尔（Presl）相关的内生菌 sp. HBQ95 进行的化学研究，发现了四种新的含哌嗪酸环缩肽——利迪亚霉素 E-H（-），以及一种已知化合物（利迪亚霉素 A）。通过光谱分析和多种化学操作相结合的方式确定了它们的化学结构，包括绝对构型。利迪亚霉素 F-H（-）和 A（）对 PANC-1 人胰腺癌细胞表现出抗转移活性，且无明显细胞毒性。
