Department of Research and Analytics (DORA), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 600077, Tamil Nadu, India.
PG and Research Department of Chemistry, Jamal Mohamed College (Autonomous) (Affiliated to Bharathidasan University), Tamil Nadu, Tiruchchirappalli, 620 020, India.
Arch Microbiol. 2024 Oct 22;206(11):442. doi: 10.1007/s00203-024-04169-z.
Streptomyces has long been considered as key sources for natural compounds discovery in medicine and agriculture. These compounds have been demonstrated to possess different biological activities, including antibiotic, antifungal, anticancer, and antiviral effects. As a result, new pharmaceuticals and antibiotics have been developed. Nevertheless, there have been only a few novel discoveries of bioactive compounds in the past decades from Streptomyces in natural habitats. There is, therefore, now a renewed search for new Streptomyces species having the potential to produce many compounds from one strain in lesser explored natural habitats that may be helpful in fighting diseases. Consequently, modern genome mining approaches are imperative for discovering structurally novel natural compounds with therapeutic applications from untapped sources. In light of these facts, endophytic Streptomyces from plants may offer new avenues for the discovery of bioactive compounds with distinctive chemical properties and activities. In the present review, we present the progress made in isolating natural compounds from endophytic Streptomyces originating from plants which have remarkable antimicrobial, cytotoxic, and antifungal properties. A different of distinct structural classes of compounds were reported from endophytic Streptomyces, such as indolosequiterpene, macrolides, flavones, peptides, naphthoquinones, and terpenoids. Further, we discussed modern genomics progress in finding biosynthetic gene clusters (BGCs) encoding compounds. Overall, this review might provide valuable insights into the potential for novel drug discovery from untapped endophytic Streptomyces in the future.
链霉菌一直被认为是医学和农业中天然化合物发现的关键来源。这些化合物已被证明具有不同的生物活性，包括抗生素、抗真菌、抗癌和抗病毒作用。因此，新的药物和抗生素已经开发出来。然而，在过去几十年中，从自然栖息地的链霉菌中仅发现了少数新的生物活性化合物。因此，现在重新开始寻找具有产生许多化合物潜力的新型链霉菌物种，这些化合物可以从较少探索的自然栖息地的一个菌株中产生，这可能有助于对抗疾病。因此，现代基因组挖掘方法对于从未开发的来源中发现具有治疗应用的结构新颖的天然化合物至关重要。鉴于这些事实，植物内生链霉菌可能为发现具有独特化学性质和活性的生物活性化合物提供新途径。在本综述中，我们介绍了从具有显著抗菌、细胞毒性和抗真菌特性的植物内生链霉菌中分离天然化合物的进展。从内生链霉菌中报道了不同结构类别的化合物，如吲哚倍半萜、大环内酯、黄酮类、肽、萘醌和萜类化合物。此外，我们讨论了寻找编码化合物的生物合成基因簇（BGCs）的现代基因组学进展。总体而言，该综述可能为未来从未开发的内生链霉菌中发现新型药物提供有价值的见解。
