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Can Allergen Immunotherapy Improve Antiviral Immunity in Patients with Allergic Asthma?

作者信息

Upham John W

机构信息

The University of Queensland Frazer Institute and Princess Alexandra Hospital Brisbane, Australia.

出版信息

Am J Respir Crit Care Med. 2023 May 1;207(9):1112-1114. doi: 10.1164/rccm.202302-0234ED.

DOI:10.1164/rccm.202302-0234ED
PMID:36812499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10161755/
Abstract
摘要

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Can Allergen Immunotherapy Improve Antiviral Immunity in Patients with Allergic Asthma?变应原免疫疗法能否改善过敏性哮喘患者的抗病毒免疫力？
Am J Respir Crit Care Med. 2023 May 1;207(9):1112-1114. doi: 10.1164/rccm.202302-0234ED.
2
Impact of allergen immunotherapy in allergic asthma.变应原免疫疗法对过敏性哮喘的影响。
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3
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[Preventive immunotherapy].[预防性免疫疗法]
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本文引用的文献

1
Allergen Immunotherapy Enhances Airway Epithelial Antiviral Immunity in Patients with Allergic Asthma (VITAL Study): A Double-Blind Randomized Controlled Trial.变应原免疫治疗增强过敏性哮喘患者气道上皮的抗病毒免疫（VITAL 研究）：一项双盲随机对照试验。
Am J Respir Crit Care Med. 2023 May 1;207(9):1161-1170. doi: 10.1164/rccm.202209-1708OC.
2
Allergen immunotherapy: past, present and future.变应原免疫治疗：过去、现在和未来。
Nat Rev Immunol. 2023 May;23(5):317-328. doi: 10.1038/s41577-022-00786-1. Epub 2022 Oct 17.
3
In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection.在实验性鼻病毒感染后第 4 天，哮喘患者体内支气管上皮干扰素反应增强。
Thorax. 2022 Sep;77(9):929-932. doi: 10.1136/thoraxjnl-2021-217389. Epub 2022 Jul 5.
4
Allergen immunotherapy effectively reduces the risk of exacerbations and lower respiratory tract infections in both seasonal and perennial allergic asthma: a nationwide epidemiological study.变应原免疫治疗有效降低季节性和常年性过敏性哮喘加重和下呼吸道感染的风险：一项全国性的流行病学研究。
Eur Respir J. 2022 Nov 17;60(5). doi: 10.1183/13993003.00446-2022. Print 2022 Nov.
5
INEXAS: A Phase 2 Randomized Trial of On-demand Inhaled Interferon Beta-1a in Severe Asthmatics.INEXAS：按需吸入重组人干扰素β-1a 在重度哮喘患者中的 2 期随机试验。
Clin Exp Allergy. 2021 Feb;51(2):273-283. doi: 10.1111/cea.13765. Epub 2020 Nov 3.
6
Enhanced plasmacytoid dendritic cell antiviral responses after omalizumab.奥马珠单抗治疗后增强浆细胞样树突状细胞抗病毒反应。
J Allergy Clin Immunol. 2018 May;141(5):1735-1743.e9. doi: 10.1016/j.jaci.2017.07.035. Epub 2017 Sep 1.
7
Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity.过敏原诱导的白介素 33 通过抑制抗病毒免疫来诱发呼吸道病毒诱导的哮喘。
J Allergy Clin Immunol. 2016 Nov;138(5):1326-1337. doi: 10.1016/j.jaci.2016.02.039. Epub 2016 Apr 25.
8
Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids.控制不佳的哮喘患者抗病毒干扰素产生减少与中性粒细胞炎症及高剂量吸入性糖皮质激素有关。
Chest. 2016 Mar;149(3):704-13. doi: 10.1016/j.chest.2015.12.018. Epub 2015 Dec 24.
9
Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations.使用奥马珠单抗或吸入性糖皮质激素强化进行季节性前治疗，以预防秋季哮喘发作。
J Allergy Clin Immunol. 2015 Dec;136(6):1476-1485. doi: 10.1016/j.jaci.2015.09.008. Epub 2015 Oct 27.
10
Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells.Th2 细胞因子损害呼吸道上皮细胞对鼻病毒的固有免疫反应。
Allergy. 2015 Aug;70(8):910-20. doi: 10.1111/all.12627. Epub 2015 Apr 24.