Professor of the Department of Obstetrics and Gynecology, Postgraduate Program in Internal Medicine and Health Sciences, Health Sciences Sector, Federal University of Paraná, Curitiba, Brazil.
Scientific Publications and Postgraduate Program in Obstetrics and Gynecology, Health Sciences Sector, Federal University of Paraná, Curitiba, Brazil.
Eur J Obstet Gynecol Reprod Biol. 2023 Apr;283:90-94. doi: 10.1016/j.ejogrb.2023.02.005. Epub 2023 Feb 11.
To report the characteristics described in the literature on a possible new "COVID-19-linked HELLP-like syndrome" in pregnant women with COVID-19: its association with the severity; prevalence; clinical; laboratory; pathophysiological and therapeutic management differences from the classic HELLP syndrome and their impact on outcomes. Observational, cohort, case-control, case-series and case-report studies were included. Data were extracted independently by the authors of the study, to ensure accuracy, consistency and performed the quality assessment. The database search resulted in 77 references, of which two satisfied the eligibility criteria. In these 2 studies we found a possible "COVID-19-linked HELLP-like syndrome", associated with severe COVID-19. There is a high possibility of the existence of "COVID-19-linked HELLP-like syndrome" and its association with severe COVID-19 in pregnant women, with a prevalence of 28,6%. Some characteristics of "COVID-19-linked HELLP-like syndrome" and the classic HELLP syndrome are similar. Differential diagnosis indicated two different types of therapeutic management: conservative for "COVID-19-linked HELLP-like syndrome" and delivery for the HELLP syndrome. HELLP clinical management is mandatory for both.
报告 COVID-19 孕妇中可能存在的新的“COVID-19 相关 HELLP 样综合征”的文献描述特征：其与严重程度、患病率、临床、实验室、病理生理和治疗管理方面与经典 HELLP 综合征的差异，及其对结局的影响。纳入了观察性、队列、病例对照、病例系列和病例报告研究。研究作者独立提取数据，以确保准确性、一致性并进行质量评估。数据库检索产生了 77 篇参考文献，其中 2 篇符合入选标准。在这 2 项研究中，我们发现了一种可能的“COVID-19 相关 HELLP 样综合征”，与严重 COVID-19 相关。在 COVID-19 孕妇中存在“COVID-19 相关 HELLP 样综合征”及其与严重 COVID-19 的高可能性，患病率为 28.6%。“COVID-19 相关 HELLP 样综合征”和经典 HELLP 综合征的一些特征相似。鉴别诊断提示了两种不同类型的治疗管理：“COVID-19 相关 HELLP 样综合征”为保守治疗，HELLP 综合征为分娩。HELLP 的临床管理对两者都是强制性的。
