Baei Payam, Daemi Hamed, Aramesh Fatemeh, Baharvand Hossein, Eslaminejad Mohamadreza Baghaban
Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Tissue Engineering, School of Advanced Technologies in Medicine, Royan Institute, Tehran, Iran.
Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Tissue Engineering, School of Advanced Technologies in Medicine, Royan Institute, Tehran, Iran.
Carbohydr Polym. 2023 May 15;308:120650. doi: 10.1016/j.carbpol.2023.120650. Epub 2023 Feb 4.
The purpose of cartilage tissue engineering is to provide artificial constructs with biological functions and mechanical features that resemble native tissue to improve tissue regeneration. Biochemical characteristics of the cartilage extracellular matrix (ECM) microenvironment provide a platform for researchers to develop biomimetic materials for optimal tissue repair. Due to the structural similarity of polysaccharides into physicochemical characteristics of cartilage ECM, these natural polymers capture special attention for developing biomimetic materials. The mechanical properties of constructs play a crucial influence in load-bearing cartilage tissues. Moreover, the addition of appropriate bioactive molecules to these constructs can promote chondrogenesis. Here, we discuss polysaccharide-based constructs that can be used to create substitutes for cartilage regeneration. We intend to focus on newly developed bioinspired materials, fine-tuning the mechanical properties of constructs, the design of carriers loaded by chondroinductive agents, and development of appropriate bioinks as a bioprinting approach for cartilage regeneration.
软骨组织工程的目的是提供具有类似于天然组织的生物学功能和机械特性的人工构建物，以促进组织再生。软骨细胞外基质（ECM）微环境的生化特性为研究人员开发用于最佳组织修复的仿生材料提供了一个平台。由于多糖与软骨ECM的物理化学特性在结构上具有相似性，这些天然聚合物在开发仿生材料方面备受关注。构建物的机械性能对负重软骨组织具有至关重要的影响。此外，向这些构建物中添加适当的生物活性分子可以促进软骨形成。在此，我们讨论可用于创建软骨再生替代物的基于多糖的构建物。我们打算重点关注新开发的受生物启发的材料、微调构建物的机械性能、软骨诱导剂负载载体的设计以及开发合适的生物墨水作为软骨再生的生物打印方法。
