Toshniwal P K, Tiku M L, Tiku K, Skosey J L
Department of Neurology, Cook County Hospital, Chicago, IL 60612.
J Neurol Sci. 1987 Sep;80(2-3):307-21. doi: 10.1016/0022-510x(87)90165-1.
Plasminogen activator (PA) has been related to the neuron migration during brain development. PA has also been shown to degrade myelin basic protein. We present data to show that neonatal Balb/c astrocytes show PA activity on 125I-fibrin coated plates. Secreted and cell associated fibrinolytic activity is detected only in the presence of plasminogen. Modulants like concanavalin A and phorbol myristate acetate enhance PA production and this function involves a transcriptional event. Dexamethasone inhibits baseline as well as concanavalin A induced enhancement of PA activity. These results raise the possibility that astrocytes may have an active role in myelinoclastic disorders and CNS developmental defects.
纤溶酶原激活剂（PA）与大脑发育过程中的神经元迁移有关。PA也已被证明可降解髓鞘碱性蛋白。我们提供的数据表明，新生Balb/c星形胶质细胞在包被有125I-纤维蛋白的平板上显示出PA活性。仅在纤溶酶原存在的情况下才能检测到分泌型和细胞相关的纤溶活性。诸如伴刀豆球蛋白A和佛波醇肉豆蔻酸酯乙酸酯等调节剂可增强PA的产生，并且此功能涉及转录事件。地塞米松可抑制基线以及伴刀豆球蛋白A诱导的PA活性增强。这些结果增加了星形胶质细胞可能在脱髓鞘疾病和中枢神经系统发育缺陷中起积极作用的可能性。
