Rigkos Dimitrios, Savvidis Ioannis, Bisbinas Alexia, Markopoulos Georgios, Bisbinas Ilias
1st Trauma and Orthopaedics Department, 424 General Military Training Hospital, Thessaloniki, GRC.
Internal Medicine Department, University of Pavia, Pavia, ITA.
Cureus. 2023 Jan 19;15(1):e33956. doi: 10.7759/cureus.33956. eCollection 2023 Jan.
Bisphosphonates have recently been used as a first-line treatment for osteoporosis. However, prolonged bisphosphonate use may be associated with insufficiency and atypical femoral fractures. In this case report, we present a patient with simultaneous bilateral insufficiency femoral fractures after using alendronate for 11 years, which were treated surgically. Our patient also had a history of a previous right femoral atypical fracture eight years before the latest ones, while on 3-year alendronate treatment. To our knowledge, it is the first patient reported with three atypical - insufficiency fractures covering all the anatomical areas of the proximal half of the femur after long-term bisphosphonate treatment.
双膦酸盐类药物最近已被用作骨质疏松症的一线治疗药物。然而，长期使用双膦酸盐类药物可能与骨量不足和非典型股骨骨折有关。在本病例报告中，我们介绍了一名在使用阿仑膦酸钠11年后同时发生双侧股骨骨量不足性骨折的患者，这些骨折通过手术进行了治疗。我们的患者在最近一次骨折发生的八年前，在接受三年阿仑膦酸钠治疗期间还曾有过一次右侧股骨非典型骨折病史。据我们所知，这是第一例报告的在长期双膦酸盐治疗后出现三例非典型 - 骨量不足性骨折且累及股骨近端一半所有解剖区域的患者。
