Portman O W, Neuringer M, Alexander M
Oregon Regional Primate Research Center, Beaverton 97006.
J Nutr. 1987 Nov;117(11):1844-51. doi: 10.1093/jn/117.11.1844.
Rhesus monkeys consumed purified diets that supplied either low or adequate levels of protein (3.8 vs. 13.9% of energy as casein) from birth until approximately 10 yr of age. A subgroup (PN) was born of mothers that also received low or control levels of protein throughout pregnancy. The deprived groups weighed significantly less than corresponding control groups. Weights of the total brain, cerebellum and brain stem were significantly reduced in the PN deprived group. Analysis of variance also indicated that low protein diets produced a significant reduction in cerebral weight. The concentrations of DNA, protein and eight different lipids from seven different sites in the central and peripheral nervous system were not greatly affected by diet. The total content of lecithin and phosphatidylethanolamine was significantly depressed in some parts of the deprived monkey brains. The deficits in brain weight of the PN group (10% for the cerebrum, 13% for the cerebellum and 18% for the brain stem) were very similar to those observed previously in 1-mo-old monkeys born of protein-deprived mothers and fed low protein diets postnatally. On the other hand, monkeys born of adequately nourished mothers and then fed low protein diets from birth up to 12 yr showed no deficit in brain weight despite reduction in body weight to less than half of control values.
恒河猴从出生到大约10岁期间食用纯化饮食，这些饮食提供低水平或充足水平的蛋白质（分别为能量的3.8%和13.9%，以酪蛋白形式提供）。一个亚组（PN）的母亲在整个孕期也接受低水平或对照水平的蛋白质。缺乏蛋白质的组体重明显低于相应的对照组。PN缺乏组的全脑、小脑和脑干重量显著降低。方差分析还表明，低蛋白饮食导致脑重量显著降低。中枢和外周神经系统七个不同部位的DNA、蛋白质和八种不同脂质的浓度受饮食影响不大。在缺乏蛋白质的猴子大脑的某些部位，卵磷脂和磷脂酰乙醇胺的总含量显著降低。PN组脑重量的不足（大脑为10%，小脑为13%，脑干为18%）与先前观察到的情况非常相似，即出生于蛋白质缺乏母亲的1个月大猴子，出生后喂食低蛋白饮食。另一方面，出生于营养充足母亲的猴子，从出生到12岁喂食低蛋白饮食，尽管体重降至对照值的一半以下，但脑重量没有不足。
