Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261053, China.
Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University; Peking University Ninth School of Clinical Medicine, Beijing 100089, China.
Acta Biochim Biophys Sin (Shanghai). 2023 Feb 22;55(4):540-547. doi: 10.3724/abbs.2023011.
Few therapeutic drugs and increased drug resistance have aggravated the current treatment difficulties of in recent years. To better understand the antifungal drug resistance mechanism and treatment strategy of cryptococcosis. In this review, by combining the fundamental features of reproduction leading to changes in its genome, we review recent research into the mechanism of four current anti-cryptococcal agents, coupled with new therapeutic strategies and the application of advanced technologies WGS and CRISPR-Cas9 in this field, hoping to provide a broad idea for the future clinical therapy of cryptococcosis.
近年来，抗真菌药物的有限选择和耐药性的增加加剧了 的治疗困境。为了更好地理解隐球菌病的抗真菌药物耐药机制和治疗策略。在这篇综述中，通过结合导致其基因组发生变化的基本繁殖特征，我们回顾了目前四种抗隐球菌药物的作用机制的最新研究，结合新的治疗策略和 WGS 和 CRISPR-Cas9 等先进技术在该领域的应用，希望为隐球菌病的未来临床治疗提供广泛的思路。
