Han Weiqiang, Liu Fengyu, Liu Guoxin, Li Hongjuan, Xu Yongqian, Sun Shiguo
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.
State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116023, P. R. China.
Chem Commun (Camb). 2023 Mar 16;59(23):3339-3359. doi: 10.1039/d2cc06219d.
The advancement and popularity of transdermal drug delivery (TDD) based on the physical transdermal enhancement technique (PTET) has opened a new paradigm for local tumor treatment. The drug can be directly delivered to the tumor site through the skin, thus avoiding the toxic side effects caused by the first-pass effect and achieving high patient compliance. Further development of PTETs has provided many options for antitumor drugs and laid the foundation for future applications of wearable closed-loop targeting drug delivery systems. In this highlight, the different types of PTETs and related mechanisms, and applications of PTET-related tumor detection and therapy are highlighted. According to their type and characteristics, PTETs are categorized as follows: (1) iontophoresis, (2) electroporation, (3) ultrasound, (4) thermal ablation, and (5) microneedles. PTET-related applications in the local treatment of tumors are categorized as follows: (1) melanoma, (2) breast tumor, (3) squamous cell carcinoma, (4) cervical tumor, and (5) others. The challenges and future prospects of existing PTETs are also discussed. This highlight will provide guidance for the design of PTET-based wearable closed-loop targeting drug delivery systems and personalized therapy for tumors.
基于物理透皮增强技术（PTET）的经皮给药（TDD）的进步与普及为局部肿瘤治疗开辟了新的范例。药物可通过皮肤直接递送至肿瘤部位，从而避免首过效应引起的毒副作用，并实现较高的患者依从性。PTET的进一步发展为抗肿瘤药物提供了多种选择，并为可穿戴闭环靶向给药系统的未来应用奠定了基础。在本综述中，重点介绍了不同类型的PTET及其相关机制，以及PTET相关的肿瘤检测与治疗应用。根据其类型和特点，PTET可分为以下几类：（1）离子导入法，（2）电穿孔，（3）超声，（4）热消融，以及（5）微针。PTET在肿瘤局部治疗中的相关应用可分为以下几类：（1）黑色素瘤，（2）乳腺肿瘤，（3）鳞状细胞癌，（4）宫颈肿瘤，以及（5）其他。还讨论了现有PTET面临的挑战和未来前景。本综述将为基于PTET的可穿戴闭环靶向给药系统的设计及肿瘤个性化治疗提供指导。
