Department of Geriatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Fujian Hypertension Research Institute, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
J Clin Hypertens (Greenwich). 2023 Mar;25(3):286-294. doi: 10.1111/jch.14649. Epub 2023 Feb 23.
Obesity and overweight are closely related to cardiovascular mortality. Arterial stiffness is one of the important risks for cardiovascular diseases and is strongly related with the cardiovascular mortality. However, the relationship between obesity and arterial stiffness is still controversial. A cross-sectional study was performed to examine the relationship of body fat percentage (BFP), an indicator of obesity, with carotid-femoral pulse wave velocity (cfPWV) in 2603 subjects (aged 58.62 ± 11.27 years, male 71.07%, hypertension 64.89%). All participants were divided into four groups according to the gender and the presence of arterial stiffening based on a value ≥10 m/s of cfPWV(group1 : male with cfPWV <10 m/s, group2 : male with cfPWV ≥10 m/s, group3 : female with cfPWV <10 m/s, group4 : female with cfPWV ≥10 m/s). Body weight, height, waist circumference, blood pressure were measured and clinical biochemical tests were recorded. cfPWV was measured using a non-invasive automatic device (Complior Analysis, France). BFP were calculated by CUN-BAE equation. The level of cfPWV was significantly increased with the increasing trend of BFP in both males and females. Stepwise multiple regression analysis revealed that SBP, DBP, HR, Hcy, BFP, FPG were independent associated with cfPWV in females and SBP, eGFR, FPG, BFP, DBP were independent associated with cfPWV in males. In the subgroups stratified by age, BFP was correlated with cfPWV only in females over 60 years old, but not in female those aged under 60 years old and males. In addition to the age and blood pressure, BFP was one of important predictor of arterial stiffening special in females aged over 60 years old.
肥胖和超重与心血管死亡率密切相关。动脉僵硬是心血管疾病的重要危险因素之一，与心血管死亡率密切相关。然而，肥胖与动脉僵硬之间的关系仍存在争议。本研究采用横断面研究方法，共纳入 2603 例研究对象（年龄 58.62±11.27 岁，男性占 71.07%，高血压占 64.89%），检测体脂百分比（BFP）作为肥胖的指标与颈股脉搏波速度（cfPWV）之间的关系。所有研究对象根据性别和 cfPWV 值（男性 cfPWV＜10 m/s 为组 1，男性 cfPWV≥10 m/s 为组 2，女性 cfPWV＜10 m/s 为组 3，女性 cfPWV≥10 m/s 为组 4）分为 4 组。测量体重、身高、腰围、血压，记录临床生化指标。使用非侵入性自动设备（Complior 分析，法国）测量 cfPWV。采用 CUN-BAE 方程计算 BFP。结果显示，无论男性还是女性，cfPWV 水平随 BFP 呈逐渐升高趋势。逐步多元回归分析显示，女性 cfPWV 与 SBP、DBP、HR、Hcy、BFP、FPG 独立相关，男性 cfPWV 与 SBP、eGFR、FPG、BFP、DBP 独立相关。在按年龄分层的亚组中，BFP 仅与 60 岁以上女性的 cfPWV 相关，与 60 岁以下女性和男性的 cfPWV 不相关。除了年龄和血压外，BFP 是 60 岁以上女性动脉僵硬的重要预测指标之一。
