Fujian Hypertension Research Institute, the First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.
Clin Exp Hypertens. 2020;42(2):146-152. doi: 10.1080/10641963.2019.1590385. Epub 2019 Apr 9.
Subjects with metabolic syndrome showed increased risk of cardiovascular events. We investigated the relationship between components of metabolic syndrome and arterial stiffness in Chinese hypertensives. 680 subjects (aged 58.44 ± 11.67 years, male 63.53%, hypertension 65.00%) were divided into five groups based on the number of known components of metabolic syndrome (MSCs) according to the criteria of 2010 Chinses Guidelines for Prevention and Management of Hypertension (0MSCs: n= 86; 1MSCs: n= 153; 2MSCs: n= 201; 3MSCs: n= 148; 4/5MSCs: n= 92.). Body weight, height, waist circumference, blood pressure and clinical biochemical tests were measured. Carotid-femoral pulse wave velocity (cfPWV) was measured using a non-invasive automatic device (Complior Analysis, France). The level of cfPWV was significantly increased with the increasing number of MSCs (8.20 ± 1.54 vs 8.72 ± 1.48 vs 9.34 ± 1.77 vs 9.64 ± 1.86 vs 9.91 ± 2.19 m/s, P<0.05). In subjects with hypertension (n= 442), cfPWV was higher than those without hypertension (n= 238) (9.59 ± 1.90 vs 8.49 ± 1.50 m/s, P<0.05) . Stepwise multiple regression analysis revealed that age, gender, the number of MSCs, heart rate as well as serum uric acid level were determinants for cfPWV (P<0.05). In the subgroups stratified by age, systolic blood pressure correlated with cfPWV in hypertensives under 55 years old, while in non-hypertensives the correlation was found after 60 years old. The arterial stiffness became significant with the increasing of the metabolic components numbers, which was independent of age, gender and blood pressure. And the presence of hypertension played the most important role in the progress of arterial stiffness even compared with age.
患有代谢综合征的受试者发生心血管事件的风险增加。我们研究了中国高血压患者代谢综合征成分与动脉僵硬度之间的关系。根据 2010 年中国高血压防治指南的标准，根据已知代谢综合征成分（MSCs）的数量将 680 名受试者（年龄 58.44±11.67 岁，男性 63.53%，高血压 65.00%）分为五组（0MSCs：n=86；1MSCs：n=153；2MSCs：n=201；3MSCs：n=148；4/5MSCs：n=92）。测量体重、身高、腰围、血压和临床生化指标。使用非侵入性自动设备（Complior 分析，法国）测量颈动脉-股动脉脉搏波速度（cfPWV）。cfPWV 水平随 MSCs 数量的增加而显著升高（8.20±1.54 与 8.72±1.48 与 9.34±1.77 与 9.64±1.86 与 9.91±2.19 m/s，P<0.05）。在高血压患者（n=442）中，cfPWV 高于无高血压患者（n=238）（9.59±1.90 与 8.49±1.50 m/s，P<0.05）。逐步多元回归分析显示，年龄、性别、MSCs 数量、心率以及血尿酸水平是 cfPWV 的决定因素（P<0.05）。在按年龄分层的亚组中，55 岁以下高血压患者的收缩压与 cfPWV 相关，而非高血压患者在 60 岁以后才相关。随着代谢成分数量的增加，动脉僵硬度变得明显，这与年龄、性别和血压无关。并且，即使与年龄相比，高血压在动脉僵硬度的进展中起着最重要的作用。
