University of Debrecen, Faculty of Medicine, Department of Obstetrics and Gynecology, Debrecen, Hungary.
Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany.
Minim Invasive Ther Allied Technol. 2023 Jun;32(3):127-135. doi: 10.1080/13645706.2023.2181091. Epub 2023 Feb 23.
The management of ectopic pregnancy is widely debated. Salpingectomy, salpingostomy, and expectant management are widely performed, but the best approach in terms of keeping good future spontaneous fertility chances is yet to be determined. We performed a retrospective analysis (Clinical Trial ID: NCT05479786) of the medical records of patients with an ultrasonographic or surgical diagnosis of tubal ectopic pregnancy that were admitted to the University of Debrecen Clinical Centre between 2012 and 2020. A total of 312 patients were included in the analysis. Patients managed expectantly and patients treated with salpingostomy had significantly higher rates of clinical pregnancy than patients treated with salpingectomy. Pregnancy outcomes and recurrence rates were comparable between the study groups. Salpingectomy was found to decrease the likelihood of conceiving spontaneously by 65%. A stratified analysis based on serum β-HCG levels demonstrated that all treatment modalities carry the same reproductive opportunities for patients presenting with β-HCG levels ≤ 1745 IU/L. Salpingectomy was found to decrease the patient's chance of achieving a natural conception. Conservative approaches should be considered with caution only when the patient's clinical condition permits, and the patient is appropriately counseled.
异位妊娠的处理存在广泛争议。输卵管切除术、输卵管造口术和期待治疗被广泛应用,但哪种方法能最大程度地保留良好的未来自然生育能力,仍有待确定。我们对 2012 年至 2020 年期间在德布勒森大学临床中心因超声或手术诊断为输卵管妊娠而入院的患者的病历进行了回顾性分析(临床试验 ID:NCT05479786)。共有 312 例患者纳入分析。与接受输卵管切除术的患者相比,接受期待治疗和输卵管造口术的患者的临床妊娠率显著更高。研究组之间的妊娠结局和复发率无差异。输卵管切除术使自然受孕的可能性降低了 65%。基于血清β-HCG 水平的分层分析表明,对于β-HCG 水平≤1745IU/L 的患者,所有治疗方法的生殖机会相同。输卵管切除术降低了患者自然受孕的机会。只有在患者的临床状况允许且适当咨询患者的情况下,才应谨慎考虑保守治疗方法。