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揭示前景:输卵管切除术作为卵巢癌预防先锋的全面综述

Unveiling the Promise: A Comprehensive Review of Salpingectomy as a Vanguard for Ovarian Cancer Prevention.

作者信息

Mundhada Priyal V, Bakshi Amey M, Thtipalli Nikhil, Yelne Seema

机构信息

Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Jan 28;16(1):e53088. doi: 10.7759/cureus.53088. eCollection 2024 Jan.

Abstract

This comprehensive review explores the potential of salpingectomy as a groundbreaking strategy for the prevention of ovarian cancer. The discussion encompasses the biological rationale behind salpingectomy, emphasizing its foundation in the tubal hypothesis, which posits the fallopian tubes as a possible origin site for certain ovarian cancers. Ongoing clinical trials and observational studies provide evolving evidence supporting the safety and efficacy of salpingectomy, particularly in high-risk populations. The procedure's ethical considerations, including its impact on fertility and equitable access, are thoroughly examined. Implications for clinical practice underscore the importance of informed decision-making, risk-benefit assessments, and the integration of emerging evidence into reproductive health discussions. Looking ahead, the future landscape of ovarian cancer prevention involves continued research, technological innovations, and collaborative efforts to ensure a holistic and evidence-based approach. The goal is to forge a future where ovarian cancer is not only treatable but also preventable, with salpingectomy potentially playing a pivotal role in this transformative journey.

摘要

这篇综述探讨了输卵管切除术作为预防卵巢癌的开创性策略的潜力。讨论涵盖了输卵管切除术背后的生物学原理,强调其基于输卵管假说,该假说认为输卵管可能是某些卵巢癌的起源部位。正在进行的临床试验和观察性研究提供了不断发展的证据,支持输卵管切除术的安全性和有效性,特别是在高危人群中。该手术的伦理考量,包括其对生育能力和公平可及性的影响,都得到了深入研究。对临床实践的影响强调了知情决策、风险效益评估以及将新出现的证据纳入生殖健康讨论的重要性。展望未来,卵巢癌预防的未来前景涉及持续研究、技术创新和合作努力,以确保采取全面且基于证据的方法。目标是打造一个卵巢癌不仅可治疗而且可预防的未来,输卵管切除术可能在这一变革性进程中发挥关键作用。

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The Evolution of and Evidence for Opportunistic Salpingectomy.机会性输卵管切除术的演变与证据
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本文引用的文献

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Salpingectomy and the Risk of Ovarian Cancer in Ontario.输卵管切除术与安大略省卵巢癌风险。
JAMA Netw Open. 2023 Aug 1;6(8):e2327198. doi: 10.1001/jamanetworkopen.2023.27198.
10
Next steps in the early detection of ovarian cancer.卵巢癌早期检测的后续步骤。
Commun Med (Lond). 2021;1. doi: 10.1038/s43856-021-00037-9. Epub 2021 Oct 5.

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