Slonkova Jana, Chudy Milos, Togtokhjargal Ariunjargal, Tomaskova Hana, Vacovska Hana, Rytirova Gisela, Dolezalova Irena
Department of Neurology, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava- Poruba, Czech Republic.
Center of Clinical Neurosciences, Faculty of Medicine University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic.
Heliyon. 2023 Feb;9(2):e13413. doi: 10.1016/j.heliyon.2023.e13413. Epub 2023 Feb 11.
To assess the impact of COVID-19 illness and pandemic era on sleep, general health, health care, and social status in patients with epilepsy in the Czech Republic.
Our designed and approved questionnaire consisted of 23 questions. We focused on (1) patients' demographic and epidemiological data regarding COVID-19, (2) subjective assessment of sleep; (3) epilepsy, and (4) perception of general health during the first year of the COVID-19 pandemic in the Czech Republic from March 2020 to May 2021. We administered the questionnaires during outpatient visits or by phone calls in three major university Czech epilepsy centers (Ostrava, Brno, Pilsen).
We enrolled 227 (100%) patients. The mean age (±SD) was 41.2 ± 14.82 years (min 18, max 86 years), and 138 (61%) were women. COVID-19 was confirmed using the PCR test method in 57 (25.1%) patients. In the pre-pandemic era, 62 (27.3%) patients reported sleep disturbances. Insomnia in 46 (74.2%) and excessive daytime sleepiness in 6 (9.7%) were the most mentioned sleep abnormalities. Nocturnal seizures predispose to sleep impairment (p = 0.014) and vivid dreams and nightmares (p = 0.033). COVID-19 infection significantly increased the risk of vivid dreams and nightmares in patients with diurnal seizures (p = 0.006). Sleep quality impairment and seizure frequency worsening [(p < 0.001) and (p = 0.001), respectively] were the most significant risk factors to perform general health deterioration regardless of having COVID-19 (p = 0.559). The most affected age group was 51+ years (p = 0.033). The three centers provided adequate outpatient care during the first year of the pandemic. The employment and social status of the patients remained unchanged (p = 0.074).
COVID- 19 infection significantly increased the occurrence of vivid dreams and nightmares in patients with diurnal seizures. Sleep quality deterioration and seizure frequency worsening significantly negatively impacted general health performance.
评估2019冠状病毒病（COVID-19）及大流行时期对捷克共和国癫痫患者睡眠、总体健康、医疗保健和社会状况的影响。
我们设计并获批的问卷包含23个问题。我们关注（1）患者关于COVID-19的人口统计学和流行病学数据，（2）睡眠的主观评估；（3）癫痫，以及（4）2020年3月至2021年5月捷克共和国COVID-19大流行第一年期间的总体健康感知。我们在捷克三个主要大学癫痫中心（俄斯特拉发、布尔诺、皮尔森）的门诊就诊期间或通过电话发放问卷。
我们纳入了227名（100%）患者。平均年龄（±标准差）为41.2±14.82岁（最小18岁，最大86岁），138名（61%）为女性。57名（25.1%）患者通过聚合酶链反应（PCR）检测方法确诊感染COVID-19。在大流行前时期，62名（27.3%）患者报告有睡眠障碍。最常提及的睡眠异常为46名（74.2%）患者存在失眠，6名（9.7%）患者存在日间过度嗜睡。夜间癫痫易导致睡眠障碍（p = 0.014）以及生动梦境和噩梦（p = 0.033）。COVID-19感染显著增加了日间癫痫患者出现生动梦境和噩梦的风险（p = 0.006）。无论是否感染COVID-19，睡眠质量受损和癫痫发作频率恶化[分别为（p < 0.001）和（p = 0.001）]是导致总体健康恶化的最显著风险因素（p = 0.559）。受影响最严重的年龄组为51岁及以上（p = 0.033）。在大流行的第一年，这三个中心提供了充足的门诊护理。患者的就业和社会状况保持不变（p = 0.074）。
COVID-19感染显著增加了日间癫痫患者生动梦境和噩梦的发生率。睡眠质量恶化和癫痫发作频率恶化对总体健康状况有显著负面影响。
