Zhao Hailing, Zhao Xiuxiu, Sun Yue, Yao Xiaomei, Zhang Wanqi
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin, China.
Heliyon. 2023 Jan 21;9(2):e13161. doi: 10.1016/j.heliyon.2023.e13161. eCollection 2023 Feb.
To investigate the effect of different iodide intake during pregnancy and lactation on thyroid function, docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA) metabolites, the expression of Krüppel-like factor KLF9 (KLF9), brain-derived neurotrophic factor (BDNF) in brain in offspring rats. In both male and female offspring rats, serum FT3, FT4 levels and the expression of KLF9, thyroid hormone receptors (TR)α, TRβ and BDNF in the hippocampal region and cerebellum were significantly increased in 5 times higher-than-normal pregnant iodide intake (5 HI) and 10 times higher-than-normal pregnant iodide intake (10 HI) group. The median levels of DHA metabolite (17-HDoHE) and EPA metabolites (15-HEPE, 17,18-EEQ, 9-HEPE and 14,15-DiHETE) were significantly increased in 5 HI and 10 HI group of offspring rats. Serum DHA, EPA metabolites and KLF9 as well as BDNF expression in brain might be potential iodine status biomarkers to reflect brain development in offspring.
为研究孕期和哺乳期不同碘摄入量对后代大鼠甲状腺功能、二十二碳六烯酸（DHA）、二十碳五烯酸（EPA）代谢产物、Krüppel样因子KLF9（KLF9）表达、脑源性神经营养因子（BDNF）在脑中表达的影响。在雄性和雌性后代大鼠中，孕期碘摄入量高于正常5倍（5HI）和高于正常10倍（10HI）组的血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）水平以及海马区和小脑中KLF9、甲状腺激素受体（TR）α、TRβ和BDNF的表达均显著增加。后代大鼠5HI和10HI组中DHA代谢产物（17-HDoHE）和EPA代谢产物（15-HEPE、17,18-EEQ、9-HEPE和14,15-DiHETE）的中位数水平显著升高。血清DHA、EPA代谢产物以及脑中的KLF9和BDNF表达可能是反映后代脑发育的潜在碘状态生物标志物。
