Adrien Vladimir, Bosc Nicolas, Fumat Hugo, Tessier Cédric, Ferreri Florian, Mouchabac Stéphane, Tareste David, Nuss Philippe
AP-HP, Sorbonne Université, Department of Psychiatry, Hôpital Saint-Antoine, Paris, France.
Infrastructure for Clinical Research in Neurosciences (iCRIN), Paris Brain Institute, Sorbonne Université, INSERM, CNRS, Paris, France.
Front Psychiatry. 2023 Feb 3;14:1089724. doi: 10.3389/fpsyt.2023.1089724. eCollection 2023.
Schizophrenia is a severe, chronic, and heterogeneous mental disorder that affects approximately 1% of the world population. Ongoing research aims at clustering schizophrenia heterogeneity into various "biotypes" to identify subgroups of individuals displaying homogeneous symptoms, etiopathogenesis, prognosis, and treatment response. The present study is in line with this approach and focuses on a biotype partly characterized by a specific membrane lipid composition. We have examined clinical and biological data of patients with stabilized schizophrenia, including the fatty acid content of their erythrocyte membranes, in particular the omega-3 docosahexaenoic acid (DHA). Two groups of patients of similar size were identified: the DHA- group ( = 19) with a lower proportion of membrane DHA as compared to the norm in the general population, and the DHAn group ( = 18) with a normal proportion of DHA. Compared to DHAn, DHA- patients had a higher number of hospitalizations and a lower quality of life in terms of perceived health and physical health. They also exhibited significant higher interleukin-6 and cortisol blood levels. These results emphasize the importance of measuring membrane lipid and immunoinflammatory biomarkers in stabilized patients to identify a specific subgroup and optimize non-pharmacological interventions. It could also guide future research aimed at proposing specific pharmacological treatments.
精神分裂症是一种严重、慢性且异质性的精神障碍，影响着全球约1%的人口。正在进行的研究旨在将精神分裂症的异质性聚类为各种“生物型”，以识别出具有相同症状、病因发病机制、预后和治疗反应的个体亚组。本研究符合这一方法，重点关注部分由特定膜脂质组成所表征的一种生物型。我们检查了病情稳定的精神分裂症患者的临床和生物学数据，包括他们红细胞膜的脂肪酸含量，特别是ω-3二十二碳六烯酸（DHA）。确定了两组规模相似的患者：DHA-组（n = 19），其膜DHA比例低于一般人群的正常水平；以及DHAn组（n = 18），其DHA比例正常。与DHAn组相比，DHA-组患者的住院次数更多，在感知健康和身体健康方面的生活质量更低。他们还表现出显著更高的白细胞介素-6和皮质醇血液水平。这些结果强调了在病情稳定的患者中测量膜脂质和免疫炎症生物标志物以识别特定亚组并优化非药物干预措施的重要性。这也可以为旨在提出特定药物治疗方法的未来研究提供指导。
