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皮质类固醇、血浆置换、阿加曲班、利妥昔单抗和西罗莫司对一名有肝素诱导的血小板减少症病史的灾难性抗磷脂综合征患者具有临床益处。

Corticosteroids, Plasmapheresis, Argatroban, Rituximab, and Sirolimus Provided Clinical Benefit for Catastrophic Antiphospholipid Syndrome in a Patient with a History of Heparin-Induced Thrombocytopenia.

作者信息

Hasan Haytham, Surjancev Ivana, Arnason Jon A, Garg Shivani, Rose William Nicholas

机构信息

Department of Pathology, University of Wisconsin Hospital, 600 Highland Ave, Madison, WI 53792, USA.

Department of Medicine, University of Wisconsin Hospital, 600 Highland Ave, Madison, WI 53792, USA.

出版信息

Case Rep Rheumatol. 2023 Feb 9;2023:3226278. doi: 10.1155/2023/3226278. eCollection 2023.

DOI:10.1155/2023/3226278
PMID:36816449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9935868/
Abstract

We report a patient with catastrophic antiphospholipid syndrome who had significant improvement after corticosteroids, plasmapheresis, argatroban, rituximab, and sirolimus. Argatroban was used instead of heparin due to a history of heparin-induced thrombocytopenia.

摘要

我们报告了一名患有灾难性抗磷脂综合征的患者，其在接受皮质类固醇、血浆置换、阿加曲班、利妥昔单抗和西罗莫司治疗后有显著改善。由于有肝素诱导的血小板减少病史，故使用阿加曲班替代肝素。

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Corticosteroids, Plasmapheresis, Argatroban, Rituximab, and Sirolimus Provided Clinical Benefit for Catastrophic Antiphospholipid Syndrome in a Patient with a History of Heparin-Induced Thrombocytopenia.皮质类固醇、血浆置换、阿加曲班、利妥昔单抗和西罗莫司对一名有肝素诱导的血小板减少症病史的灾难性抗磷脂综合征患者具有临床益处。
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Medicina (Kaunas). 2021 Aug 31;57(9):912. doi: 10.3390/medicina57090912.
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Expert Rev Clin Immunol. 2021 Apr;17(4):385-394. doi: 10.1080/1744666X.2021.1900733. Epub 2021 Mar 17.
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Current Promising Biomarkers and Methods in the Diagnostics of Antiphospholipid Syndrome: A Review.抗磷脂综合征诊断中当前有前景的生物标志物和方法：综述
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