Wu Tong, Liu Ying, Ali Nasra Mohamoud, Zhang Bin, Cui Xiaonan
Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, P.R. China.
Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116011, P.R. China.
ACS Omega. 2023 Jan 31;8(6):5157-5168. doi: 10.1021/acsomega.2c06567. eCollection 2023 Feb 14.
Exosomes are lipid bilayer vesicles in biological fluids, which can participate in biological processes by mediating intercellular communication and activating intracellular signaling pathways, especially cancerogenic processes, such as proliferation, metastasis, invasion, and immune regulation of cancer cells. Besides, cancer-derived exosomes are also involved in tumor diagnosis and therapy as biomarkers and nanotransport devices. This article reviews the latest research progress on the biological regulation and disease diagnosis of exosomes in tumors, with the aim of providing new ideas for the clinical treatment of cancers.
外泌体是生物流体中的脂质双层囊泡，可通过介导细胞间通讯和激活细胞内信号通路参与生物过程，尤其是致癌过程，如癌细胞的增殖、转移、侵袭和免疫调节。此外，癌症来源的外泌体还作为生物标志物和纳米转运装置参与肿瘤诊断和治疗。本文综述了外泌体在肿瘤中的生物学调控和疾病诊断方面的最新研究进展，旨在为癌症的临床治疗提供新思路。
