持续气道正压通气可能通过抑制炎症和氧化应激来改善阻塞性睡眠呼吸暂停低通气综合征患者的高血压。
Continuous positive airway pressure may improve hypertension in patients with obstructive sleep apnea-hypopnea syndrome by inhibiting inflammation and oxidative stress.
作者信息
Wang Xiaoting, Guan Liying, Wu Changzhen, Zhao Yongjun, Zhao Gang
机构信息
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Health Management Center, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
出版信息
Arch Med Sci. 2022 Dec 9;19(1):237-241. doi: 10.5114/aoms/156490. eCollection 2023.
INTRODUCTION
The work was designed to investigate the effect of continuous positive airway pressure (CPAP) on hypertension in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and to elucidate the underlying mechanisms.
METHODS
We examined the effect of CPAP on blood pressure and biomarkers reflecting inflammation and oxidative stress, and investigated the correlation between changes in blood pressure and the biomarkers.
RESULTS
CPAP significantly improved clinic, ambulatory and home blood pressure ( < 0.05). The hypotensive effect of CPAP was positively correlated with the decrease of interleukin-6, C-reactive protein, NADPH oxidase and malonaldehyde.
CONCLUSIONS
CPAP has a significant antihypertensive effect on OSAHS patients, especially nocturnal hypertension, possibly by counteracting inflammation and oxidative stress.
引言
本研究旨在探讨持续气道正压通气（CPAP）对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者高血压的影响，并阐明其潜在机制。
方法
我们检测了CPAP对血压以及反映炎症和氧化应激的生物标志物的影响，并研究了血压变化与生物标志物之间的相关性。
结果
CPAP显著改善了诊室血压、动态血压和家庭血压（P<0.05）。CPAP的降压作用与白细胞介素-6、C反应蛋白、NADPH氧化酶和丙二醛的降低呈正相关。
结论
CPAP对OSAHS患者有显著的降压作用，尤其是对夜间高血压，可能是通过对抗炎症和氧化应激来实现的。
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