Kara Gedik Gonca, Yılmaz Farise, Önner Hasan
Selçuk University Faculty of Medicine, Department of Nuclear Medicine, Konya, Turkey.
Mol Imaging Radionucl Ther. 2023 Feb 23;32(1):20-27. doi: 10.4274/mirt.galenos.2022.71463.
Oligometastases may generate secondary to indolent tumor biology. In this study, we investigated whether semiquantitative measures of F-fluorodeoxyglucose (FDG) and gallium-68 (Ga) prostate-specific membrane antigen (PSMA) uptake of metastatic lesions and prostatic sites are different between oligometastatic (OM) and multimetastatic (MM) disease of prostate carcinoma (PC).
Patients with PC, who underwent positron emission tomography/computed tomography (PET/CT) from October 2012 to February 2020 were retrospectively reviewed. Patients, whose reports were consistent with metastatic diseases were selected. Patients classified as with MM or OM disease. Maximum standardized uptake values (SUV) were calculated from metastatic lesions and the prostatic site. The median of the SUV results between patients with OM and MM disease were compared.
A totally 145 patients with a mean age of 71.46±9.26, were evaluated. In 59 of 145 patients, F-FDG PET/CT was performed;86 patients had gone through Ga PSMA PET/CT. Thirty-seven of 145 patients were OM, whereas 108 patients were MM. The median of the SUV of metastatic lesions in patients with OM and MM disease in the F-FDG group were 5.60 and 9.51, respectively. The results of the calculated median SUV values in OM and MM disease in the Ga-68 PSMA group were 13.44 and 29.84, respectively. A significant difference was observed in the median SUV results of metastatic lesions between OM and MM disease (p<0.05). Median values of SUV calculated from the prostatic site in OM and MM disease were 7.83 and 12.29 respectively in F-FDG; 26.23 and 26.74 in the Ga PSMA group. No significant difference was found in the SUV results of the prostatic site between OM and MM disease (p>0.05).
SUV results of metastatic lesions are significantly higher in patients with MM than in patients with OM disease in patients with PC, which may be secondary to their different biological contents in terms of aggressiveness.
寡转移可能继发于惰性肿瘤生物学特性。在本研究中，我们调查了前列腺癌（PC）寡转移（OM）和多转移（MM）疾病中，转移性病灶和前列腺部位的氟脱氧葡萄糖（FDG）及镓-68（Ga）前列腺特异性膜抗原（PSMA）摄取的半定量指标是否存在差异。
回顾性分析2012年10月至2020年2月期间接受正电子发射断层扫描/计算机断层扫描（PET/CT）的PC患者。选择报告符合转移性疾病的患者，并分为MM或OM疾病组。计算转移性病灶和前列腺部位的最大标准化摄取值（SUV）。比较OM和MM疾病患者SUV结果的中位数。
共评估了145例平均年龄为71.46±9.26岁的患者。145例患者中，59例进行了F-FDG PET/CT检查；86例接受了Ga PSMA PET/CT检查。145例患者中，37例为OM，108例为MM。F-FDG组中，OM和MM疾病患者转移性病灶的SUV中位数分别为5.60和9.51。Ga-68 PSMA组中，OM和MM疾病患者计算得到的SUV中位数结果分别为13.44和29.84。OM和MM疾病转移性病灶的SUV中位数结果存在显著差异（p<0.05）。F-FDG中，OM和MM疾病前列腺部位计算得到的SUV中位数分别为7.83和12.29；Ga PSMA组中分别为26.23和26.74。OM和MM疾病前列腺部位的SUV结果无显著差异（p>0.05）。
PC患者中，MM患者转移性病灶的SUV结果显著高于OM疾病患者，这可能继发于其侵袭性方面不同的生物学内容。
