Erdoğan Mehmet, Özkan Emine Elif, Öztürk Sefa Alperen, Yıldız Mustafa, Şengül Sevim Süreyya
Süleyman Demirel University Faculty of Medicine, Department of Nuclear Medicine, Isparta, Turkey
Süleyman Demirel University Faculty of Medicine, Department of Radiation Oncology, Isparta, Turkey
Mol Imaging Radionucl Ther. 2020 Oct 19;29(3):98-104. doi: 10.4274/mirt.galenos.2020.89421.
In this study, we aimed to investigate whether Ga-68 prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) scanning is adequate to predict intermediate risk, high risk, or oligometastatic prostate cancer (PCa) as an initial staging modality.
The Ga-68 PSMA PET/CT scan images of 50 PCa patients pathologically proven by transrectal ultrasound guided biopsy were evaluated retrospectively. The association of standard uptake value maximum (SUV) value of the area with the highest PSMA expression within the primary tumor with the risk groups and metastatic burden is investigated.
The SUV value was 6.18 in oligometastatic patients where it was measured as 10.93 in patients with higher metastatic burden (p=0.037). The cut-off SUV value for multiple metastases was 7.96 (p=0.047). According to the regression model, SUV value has a positive influence [odds ratio (OR)=1.42], which was statistically significant (p=0.038). SUV values for intermediate and high risk patients were 6.91 and 11.44, respectively (p=0.014). The cut-off SUV value for the high risk group was 10.55 (p=0.006). In the regression model, SUV value has a positive influence (OR=1.198), which was statistically significant (p=0.021).
In this paper, we demonstrated the association between SUV value of primary tumor and Gleason score. Our results also allowed us to suggest that primary tumor SUV is a sufficiently accurate predictor of D'Amico risk groups in newly diagnosed PCa cases. Additionally, Ga-68 PSMA PET/CT turns out to be a useful tool in determining oligometastatic PCa, which requires a different treatment approach.
在本研究中，我们旨在调查镓-68前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描（PSMA PET/CT）扫描作为一种初始分期方式，是否足以预测中危、高危或寡转移前列腺癌（PCa）。
回顾性评估经直肠超声引导活检病理证实的50例PCa患者的镓-68 PSMA PET/CT扫描图像。研究原发肿瘤内PSMA表达最高区域的标准摄取值最大值（SUV）与风险组和转移负担之间的关联。
寡转移患者的SUV值为6.18，转移负担较高的患者中该值为10.93（p=0.037）。多发转移的SUV临界值为7.96（p=0.047）。根据回归模型，SUV值具有正向影响[比值比（OR）=1.42]，具有统计学意义（p=0.038）。中危和高危患者的SUV值分别为6.91和11.44（p=0.014）。高危组的SUV临界值为10.55（p=0.006）。在回归模型中，SUV值具有正向影响（OR=1.198），具有统计学意义（p=0.021）。
在本文中，我们证明了原发肿瘤SUV值与Gleason评分之间的关联。我们的结果还使我们能够提出，原发肿瘤SUV是新诊断PCa病例中D'Amico风险组的一个足够准确的预测指标。此外，镓-68 PSMA PET/CT被证明是确定寡转移PCa的有用工具，而寡转移PCa需要不同的治疗方法。
