Wang Xiao Jie, Bai Xue, Miu Ying, Chen Pan, Yan Pi Jun, Jiang Chun Xia
Southwest Medical University, Affiliated Hospital, Department of Endocrinology and Metabolism, Luzhou City, Sichuan Province, China.
J Med Biochem. 2023 Jan 20;42(1):86-93. doi: 10.5937/jomb0-35877.
This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.
From January 2019 to June 2021, 79 cases of POP patients were selected as the research objects. A test of the patients' bone density was conducted, and clinical grading of POP was via T value (normal, mild, moderate, severe). The analysis of the assessment value of pathological condition of serum APN and amylin for POP and their association with bone metabolism indexes in patients was performed.
APN and amylin in patients were declined with POP's aggravation. APN of 5.15 μg/mL or less and amylin of 15.38 pmol/L or less were risk factors influencing the aggravation of pathological condition of POP (< 0 .0 5). The area under the curve (AUC) of combined detection of APN and amylin to assess the severity of POP was elevated vs. alone test of amylin (< 0.05). 25-hydroxyvitamin D (25-(OH) D) and total type 1 procollagen amino-terminal propeptide (t-PINP) in patients were descended with the aggravation of pathological condition of osteoporosis ( < 0.05). At the same time, no distinct differences were presented in the three groups of type I collagen hydroxyl terminal peptide b degradation product (β-CTX) and N-terminal osteocalcin (N-MID) (P> 0.05). APN, amylin, 25-(OH)D, β-CTX, and t-PINP were negatively linked with POP clinical grade (< 0.05). APN and amylin were associated with 25-(OH) D, β-CTX, t-PINP (< 0.05), and APN and amylin were not linked with N-MID (> 0.05).
Serum APN and amylin are provided with evaluation values for the severity of POP and are associated with bone metabolism in patients.
本文探讨血清脂联素（APN）和胰淀素的病理状况对原发性骨质疏松症（POP）的评估价值及其与骨代谢指标的相关性。
选取2019年1月至2021年6月期间79例POP患者作为研究对象。对患者进行骨密度检测，POP的临床分级依据T值（正常、轻度、中度、重度）。分析血清APN和胰淀素的病理状况对POP的评估价值及其与患者骨代谢指标的关联。
患者的APN和胰淀素水平随POP病情加重而下降。APN低于5.15μg/mL且胰淀素低于15.38pmol/L是影响POP病情加重的危险因素（<0.05）。联合检测APN和胰淀素评估POP严重程度的曲线下面积（AUC）高于单独检测胰淀素（<0.05）。患者的25-羟维生素D（25-(OH)D）和总Ⅰ型前胶原氨基端前肽（t-PINP）水平随骨质疏松病情加重而降低（<0.05）。同时，Ⅰ型胶原羟基末端肽b降解产物（β-CTX）和N端骨钙素（N-MID）在三组中无明显差异（P>0.05）。APN、胰淀素、25-(OH)D、β-CTX和t-PINP与POP临床分级呈负相关（<0.05）。APN和胰淀素与25-(OH)D、β-CTX、t-PINP相关（<0.05），且APN和胰淀素与N-MID无关联（>0.05）。
血清APN和胰淀素对POP严重程度具有评估价值，且与患者骨代谢相关。
