Yakout Sobhy M, Alharbi Fatimah, Abdi Saba, Al-Daghri Nasser M, Al-Amro Abir, Khattak Malak Nawaz Khan
Biochemistry Department, College of Science.
Department of Biochemistry, Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh, Saudi Arabia.
Medicine (Baltimore). 2020 Jul 2;99(27):e20840. doi: 10.1097/MD.0000000000020840.
Osteoporosis is reported to be common among Saudi women. Several minerals appear to be important determinants of insulin-like growth factor (IGF), the bioactivity of which regulates bone and mineral metabolism. Here we proposed that mineral status may alter the IGF system among individuals with osteoporosis. This study aims to evaluate the relationships between essential elements and IGF levels among postmenopausal Saudi women with osteoporosis. A total of 128 postmenopausal Saudi women aged ≥50 years old were recruited in this study. Diagnosis of osteoporosis was done by using dual-energy x-ray absorptiometry to determine the bone minerals density (BMD). Serum calcium and phosphate were determined using routine chemical analyzer. Serum Co, Mn, Ni, Cd were measured using inductively coupled plasma mass spectrometry. Serum IGF-1 and IGF-2 were determined using Luminex xMAP. Using stepwise linear regression analysis, only Cd was identified to be significantly associated with IGF1 in osteoporosis, explaining 3% (confidence interval 0.01-0.05; P = 0001) of the variance perceived. Our results suggest that Cd exposure indirectly affects BMD which may increase the risk of osteoporosis in postmenopausal women. Further longitudinal study using a larger sample size is recommended to determine causality of Cd levels and IGF-1.
据报道，骨质疏松症在沙特女性中很常见。几种矿物质似乎是胰岛素样生长因子（IGF）的重要决定因素，其生物活性调节骨骼和矿物质代谢。在此，我们提出矿物质状态可能会改变骨质疏松症患者的IGF系统。本研究旨在评估绝经后患有骨质疏松症的沙特女性体内必需元素与IGF水平之间的关系。本研究共招募了128名年龄≥50岁的绝经后沙特女性。通过使用双能X线吸收法测定骨矿物质密度（BMD）来诊断骨质疏松症。使用常规化学分析仪测定血清钙和磷。使用电感耦合等离子体质谱法测量血清中的钴（Co）、锰（Mn）、镍（Ni）、镉（Cd）。使用Luminex xMAP测定血清IGF-1和IGF-2。通过逐步线性回归分析，仅发现镉与骨质疏松症患者的IGF1显著相关，解释了所观察到的3%的方差（置信区间0.01 - 0.05；P = 0.001）。我们的结果表明，镉暴露会间接影响骨矿物质密度，这可能会增加绝经后女性患骨质疏松症的风险。建议使用更大样本量进行进一步的纵向研究，以确定镉水平与IGF-1之间的因果关系。
