Kayikcioglu Erkan, Iscan Gokce
Department of Medical Oncology, Suleyman Demirel University School of Medicine, Isparta, TUR.
Department of Family Medicine, Suleyman Demirel University School of Medicine, Isparta, TUR.
Cureus. 2023 Jan 15;15(1):e33808. doi: 10.7759/cureus.33808. eCollection 2023 Jan.
Objective Systemic inflammation and nutrition are associated with survival outcomes in metastatic colon cancer (mCC) patients. A new and strong prognostic marker named the Prognostic Immune Nutritional Index (PINI) was proposed as the best marker for outcomes in metastatic colon cancer patients. This study aimed to evaluate the prognostic significance of PINI in mCC patients. Methods The data of 190 patients who were admitted to our center and diagnosed with mCC between 2010 and 2020 abiding by our inclusion criteria were reviewed retrospectively. Receiver operating characteristic (ROC) analysis was used to identify the optimum cutoff value of PINI for overall survival (OS). Results The mean age of the participants was 62.64±11.99 years. The median follow-up time was 25.81 months. According to PINI, the median OS in patients who had PINI<3 was 22.70 months (95% confidence interval (CI): 16.05-29.35), and the median OS in patients who had PINI≥3 was 38.83 months (95% CI: 26.98-37.01) (p<0.001). PINI score lower than 3 was an independent prognostic indicator in multivariate analysis. Conclusions PINI was discovered to be an independent prognostic factor in metastatic colorectal cancer. We believe that PINI, which can be calculated using a simple formula, will provide clinicians with important clues when deciding on individual treatment.
目的 全身炎症和营养状况与转移性结肠癌（mCC）患者的生存结局相关。一种名为预后免疫营养指数（PINI）的新型强效预后标志物被提出，作为转移性结肠癌患者预后的最佳标志物。本研究旨在评估PINI在mCC患者中的预后意义。方法 回顾性分析2010年至2020年间符合纳入标准入住本中心并诊断为mCC的190例患者的数据。采用受试者工作特征（ROC）分析确定PINI对总生存期（OS）的最佳截断值。结果 参与者的平均年龄为62.64±11.99岁。中位随访时间为25.81个月。根据PINI，PINI<3的患者中位OS为22.70个月（95%置信区间（CI）：16.05 - 29.35），PINI≥3的患者中位OS为38.83个月（95% CI：26.98 - 37.01）（p<0.001）。在多因素分析中，PINI评分低于3是独立的预后指标。结论 发现PINI是转移性结直肠癌的独立预后因素。我们认为，PINI可通过简单公式计算得出，在临床医生决定个体化治疗时将为其提供重要线索。
