An Sanghyun, Shim Hongjin, Kim Kwangmin, Kim Bora, Bang Hui-Jae, Do Hyejin, Lee Hyang-Rae, Kim Youngwan
Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
Division of Gastroenterology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Ann Coloproctol. 2022 Apr;38(2):97-108. doi: 10.3393/ac.2021.01004.0143. Epub 2022 Mar 29.
We aimed to review whether pretreatment inflammatory markers reflect the short- and long-term outcomes of patients with colon cancer, rectal cancer, colon and rectal cancers, and metastatic colorectal cancer (CRC). We found that pretreatment complete blood count and blood chemistry tests reflect short-term and long-term oncological outcomes in patients with CRC. Specifically, in patients with colon cancer, hypoalbuminemia was associated with worse postoperative morbidity, mortality, and inferior survival. In patients with rectal cancer, elevated neutrophil-lymphocyte ratio (NLR) and thrombocytosis were associated with postoperative complications, poor overall survival (OS), and disease-free survival (DFS). A high C-reactive protein/albumin ratio (CAR) was associated with poor OS and DFS. In patients with metastatic CRC, increased NLR and platelet-lymphocyte ratio (PLR) were associated with poor OS, DFS, and progression-free survival (PFS). In addition, high CAR and a low albumin/globulin ratio on blood chemistry tests were associated with poor OS and PFS. Although universal cut-off values were not available, various types of pretreatment laboratory markers could be utilized as adjuncts to predict prognosis in patients with CRC.
我们旨在回顾术前炎症标志物是否能反映结肠癌、直肠癌、结直肠癌以及转移性结直肠癌（CRC）患者的短期和长期预后。我们发现，术前全血细胞计数和血液化学检查能反映CRC患者的短期和长期肿瘤学预后。具体而言，在结肠癌患者中，低白蛋白血症与术后更高的发病率、死亡率以及较差的生存率相关。在直肠癌患者中，中性粒细胞与淋巴细胞比值（NLR）升高和血小板增多与术后并发症、较差的总生存期（OS）和无病生存期（DFS）相关。高C反应蛋白/白蛋白比值（CAR）与较差的OS和DFS相关。在转移性CRC患者中，NLR升高和血小板与淋巴细胞比值（PLR）升高与较差的OS、DFS和无进展生存期（PFS）相关。此外，血液化学检查中高CAR和低白蛋白/球蛋白比值与较差的OS和PFS相关。尽管没有通用的临界值，但各种类型的术前实验室标志物可作为辅助手段来预测CRC患者的预后。
