水化程度降低的微管结构。X射线衍射和电子显微镜结果的比较。

Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy.

作者信息

Beese L, Stubbs G, Thomas J, Cohen C

机构信息

Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254.

出版信息

J Mol Biol. 1987 Aug 5;196(3):575-80. doi: 10.1016/0022-2836(87)90033-7.

DOI:10.1016/0022-2836(87)90033-7

PMID:3681968

Abstract

A recent model for the structure of microtubules is used to interpret X-ray fiber diffraction patterns from microtubules, obtained under various conditions. The results suggest that tubulin may undergo conformational changes under conditions of reduced water-activity. Such changes could account for some of the differences in the structure of tubulin as determined by electron microscopy and X-ray diffraction.

摘要

一种最新的微管结构模型被用于解释在各种条件下获得的微管X射线纤维衍射图谱。结果表明，在水分活性降低的条件下，微管蛋白可能会发生构象变化。这种变化可以解释通过电子显微镜和X射线衍射测定的微管蛋白结构中的一些差异。