College of Marine Life Sciences, Ocean University of China, Qingdao, China.
Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Oxid Med Cell Longev. 2023 Feb 8;2023:4985726. doi: 10.1155/2023/4985726. eCollection 2023.
Nicotinamide adenine dinucleotide (NAD) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. NAD is also required as a cofactor by nonredox NAD-dependent enzymes. Hundreds of enzymes that consume NAD have been identified. The NAD-consuming enzymes are involved in a variety of cellular processes such as signal transduction, DNA repair, cellular senescence, and stem cell (SC) homeostasis. In this review, we discussed how different types of NAD-consuming enzymes regulate SC functions and summarized current research on the roles of the NAD consumers in SC homeostasis. We hope to provide a more global and integrative insight to the mechanism and intervention of SC homeostasis the regulation of the NAD-consuming enzymes.
烟酰胺腺嘌呤二核苷酸（NAD）是一种在氧化还原反应、能量代谢和线粒体生物发生中使用的辅酶。NAD 也被非氧化还原 NAD 依赖的酶用作辅助因子。已经鉴定出数百种消耗 NAD 的酶。消耗 NAD 的酶参与各种细胞过程，如信号转导、DNA 修复、细胞衰老和干细胞（SC）稳态。在这篇综述中，我们讨论了不同类型的消耗 NAD 的酶如何调节 SC 功能，并总结了目前关于 NAD 消耗者在 SC 稳态中的作用的研究。我们希望为 SC 稳态调控 NAD 消耗酶的机制和干预提供更全面和综合的见解。
