SARM1 可能成为治疗脊髓损伤的一个潜在靶点。
SARM1 can be a potential therapeutic target for spinal cord injury.
机构信息
Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, China.
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
出版信息
Cell Mol Life Sci. 2022 Feb 28;79(3):161. doi: 10.1007/s00018-022-04195-4.
Abstract
Injury to the spinal cord is devastating. Studies have implicated Wallerian degeneration as the main cause of axonal destruction in the wake of spinal cord injury. Therefore, the suppression of Wallerian degeneration could be beneficial for spinal cord injury treatment. Sterile alpha and armadillo motif-containing protein 1 (SARM1) is a key modulator of Wallerian degeneration, and its impediment can improve spinal cord injury to a significant degree. In this report, we analyze the various signaling domains of SARM1, the recent findings on Wallerian degeneration and its relation to axonal insults, as well as its connection to SARM1, the mitogen-activated protein kinase (MAPK) signaling, and the survival factor, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2). We then elaborate on the possible role of SARM1 in spinal cord injury and explicate how its obstruction could potentially alleviate the injury.
摘要
脊髓损伤是毁灭性的。研究表明，Wallerian 变性是脊髓损伤后轴突破坏的主要原因。因此，抑制 Wallerian 变性可能有益于脊髓损伤的治疗。无菌α和装甲蛋白 1（SARM1）是 Wallerian 变性的关键调节剂，其抑制作用可显著改善脊髓损伤。在本报告中，我们分析了 SARM1 的各种信号结构域、Wallerian 变性及其与轴突损伤的关系的最新发现，以及它与丝裂原活化蛋白激酶（MAPK）信号和生存因子烟酰胺单核苷酸腺苷酰转移酶 2（NMNAT2）的关系。然后，我们详细阐述了 SARM1 在脊髓损伤中的可能作用，并解释了其阻断如何可能减轻损伤。
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