Fukushima Takuya, Tanaka Takashi, Fukushima Suguru, Watanabe Mizuki, Aoki Jun, Ito Ayumu, Inamoto Yoshihiro, Kim Sung-Won, Kawai Akira, Fukuda Takahiro
Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Japan.
Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Japan.
Phys Ther Res. 2022;25(3):162-167. doi: 10.1298/ptr.E10196. Epub 2022 Dec 22.
Physical activity (PA) interventions positively affect the physical function (PF) in patients with advanced cancer. However, patients must remain motivated during the intervention. We report a case wherein a smartphone application for PA intervention was useful in motivating the patient to improve adherence.
A 40-year-old woman underwent an allogeneic hematopoietic cell transplantation (allo-HCT) for an advanced extranodal natural killer/T-cell lymphoma. On day 6, she developed the posterior reversible encephalopathy syndrome. She was managed in the intensive care unit for 3 days, and her PF declined markedly. We initiated a smartphone-based PA intervention from day 35. She was instructed to maintain a PA diary for self-monitoring of the daily steps and to set a new step-count goal every week.
The PA and PF improved within a short period thereafter. However, she developed severe acute graft-versus-host disease and was administered with high-dose systemic corticosteroids from day 49. The PA, PF, and quality of life (QOL) decreased again. The intervention was continued for 5 months with a high adherence. The PA, PF, and QOL improved gradually. She resumed independent activities of daily living and was discharged on day 202.
Smartphone-based PA intervention may be effective against post-allo-HCT physical dysfunction.
体育活动（PA）干预对晚期癌症患者的身体功能（PF）有积极影响。然而，患者在干预过程中必须保持积极性。我们报告了一例使用智能手机应用程序进行PA干预有助于激发患者提高依从性的病例。
一名40岁女性因晚期结外自然杀伤/T细胞淋巴瘤接受了异基因造血细胞移植（allo-HCT）。在第6天，她出现了后部可逆性脑病综合征。她在重症监护病房接受了3天治疗，其PF明显下降。我们从第35天开始基于智能手机进行PA干预。指导她记录PA日记以自我监测每日步数，并每周设定一个新的步数目标。
此后短期内PA和PF均有所改善。然而，她出现了严重的急性移植物抗宿主病，从第49天开始接受高剂量全身皮质类固醇治疗。PA、PF和生活质量（QOL）再次下降。干预持续了5个月，依从性很高。PA、PF和QOL逐渐改善。她恢复了独立的日常生活活动，并于第202天出院。
基于智能手机的PA干预可能对allo-HCT后的身体功能障碍有效。
