El Mahmoudi Nada, Laurent Célia, Péricat David, Watabe Isabelle, Lapotre Agnès, Jacob Pierre-Yves, Tonetto Alain, Tighilet Brahim, Sargolini Francesca
Aix-Marseille Université -CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, Centre Saint Charles, Case C; 3 Place Victor Hugo, 13331, Marseille Cedex 03, France.
Aix-Marseille Université -CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, Centre Saint Charles, Case C; 3 Place Victor Hugo, 13331, Marseille Cedex 03, France.
Prog Neurobiol. 2023 Apr;223:102403. doi: 10.1016/j.pneurobio.2023.102403. Epub 2023 Feb 21.
Unilateral vestibular loss (UVL) induces a characteristic vestibular syndrome composed of various posturo-locomotor, oculomotor, vegetative and perceptivo-cognitive symptoms. Functional deficits are progressively recovered over time during vestibular compensation, that is supported by the expression of multiscale plasticity mechanisms. While the dynamic of post-UVL posturo-locomotor and oculomotor deficits is well characterized, the expression over time of the cognitive deficits, and in particular spatial memory deficits, is still debated. In this study we aimed at investigating spatial memory deficits and their recovery in a rat model of unilateral vestibular neurectomy (UVN), using a wide spectrum of behavioral tasks. In parallel, we analyzed markers of hippocampal plasticity involved in learning and memory. Our results indicate the UVN affects all domains of spatial memory, from working memory to reference memory and object-in-place recognition. These deficits are associated with long-lasting impaired plasticity in the ipsilesional hippocampus. These results highlight the crucial role of symmetrical vestibular information in spatial memory and contribute to a better understanding of the cognitive disorders observed in vestibular patients.
单侧前庭丧失（UVL）会引发一种由各种姿势运动、眼球运动、自主神经以及感知认知症状组成的典型前庭综合征。在前庭代偿过程中，功能缺陷会随着时间逐渐恢复，这一过程受到多尺度可塑性机制表达的支持。虽然UVL后姿势运动和眼球运动缺陷的动态变化已得到充分表征，但认知缺陷，尤其是空间记忆缺陷随时间的表现仍存在争议。在本研究中，我们旨在使用广泛的行为任务，研究单侧前庭神经切除术（UVN）大鼠模型中的空间记忆缺陷及其恢复情况。同时，我们分析了参与学习和记忆的海马可塑性标记物。我们的结果表明，UVN会影响空间记忆的所有领域，从工作记忆到参考记忆以及物体位置识别。这些缺陷与同侧海马中长期受损的可塑性有关。这些结果突出了对称前庭信息在空间记忆中的关键作用，并有助于更好地理解前庭患者中观察到的认知障碍。
