Aix Marseille Université-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, France.
GDR Vertige CNRS Unité GDR2074, 13331 Marseille, France.
Int J Mol Sci. 2024 Jan 24;25(3):1422. doi: 10.3390/ijms25031422.
In this review, we explore the intriguing realm of neurogenesis in the vestibular nuclei-a critical brainstem region governing balance and spatial orientation. We retrace almost 20 years of research into vestibular neurogenesis, from its discovery in the feline model in 2007 to the recent discovery of a vestibular neural stem cell niche. We explore the reasons why neurogenesis is important in the vestibular nuclei and the triggers for activating the vestibular neurogenic niche. We develop the symbiotic relationship between neurogenesis and gliogenesis to promote vestibular compensation. Finally, we examine the potential impact of reactive neurogenesis on vestibular compensation, highlighting its role in restoring balance through various mechanisms.
在这篇综述中，我们探讨了前庭神经核中神经发生的迷人领域——这是一个控制平衡和空间定位的关键脑干区域。我们回顾了近 20 年来对前庭神经发生的研究，从 2007 年在猫模型中的发现到最近发现的前庭神经干细胞龛。我们探讨了神经发生在前庭神经核中的重要性以及激活前庭神经发生龛的触发因素。我们发展了神经发生和神经胶质发生之间的共生关系，以促进前庭代偿。最后，我们研究了反应性神经发生对前庭代偿的潜在影响，强调了它通过各种机制恢复平衡的作用。
