不同斑块类型之间的冠状动脉周围脂肪组织差异：一项回顾性评估
Pericoronary adipose tissue differences among plaque types: a retrospective assessment.
作者信息
Jing Mengyuan, Sun Jianqing, Zhou Qing, Sun Jiachen, Li Xiangwen, Xi Huaze, Zhang Bin, Lin Xiaoqiang, Deng Liangna, Han Tao, Zhou Junlin
机构信息
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China; Second Clinical School, Lanzhou University, Lanzhou, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China; Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou, China.
Shanghai United Imaging Research Institute of Intelligent Imaging, Shanghai, China.
出版信息
Clin Imaging. 2023 Apr;96:58-63. doi: 10.1016/j.clinimag.2023.02.009. Epub 2023 Feb 17.
PURPOSE
To assess differences in pericoronary adipose tissue (PCAT) in patients with different plaque types by using several quantitative parameters of PCAT and investigate the relationship between PCAT and different plaque types.
MATERIALS AND METHODS
We retrospectively recruited 488 patients diagnosed with stable coronary artery disease (CAD) via coronary computed tomographic angiography, including 279 with calcified plaques (CP), 153 with non-calcified plaques (NCP), and 56 with mixed plaques (MP). Volume, fat attenuation index (FAI), and 10 percentile, 90 percentile, median, and minimum Hounsfield unit (HU) values of PCAT surrounding plaques were quantified. Clinical features and quantitative PCAT parameters were compared between different plaque types.
RESULTS
No intergroup differences were observed for age, sex, body mass index, risk factors, and plaque location. Length and PCAT volume in the NCP group were lower than those of the CP and MP groups (P < 0.001), whereas there were no significant differences between the CP and MP groups (P > 0.05). Patients with NCP and MP had a higher FAI and 10 percentile, 90 percentile, median, and minimum HU values of PCAT than CP (P < 0.001); however these values were not significantly different between the NCP and MP groups (P > 0.05).
CONCLUSION
The quantitative parameters of PCAT, as a biosensor for CAD, vary among the different plaque types.
目的
通过使用冠状动脉周围脂肪组织（PCAT）的几个定量参数，评估不同斑块类型患者的PCAT差异，并研究PCAT与不同斑块类型之间的关系。
材料与方法
我们回顾性招募了488例经冠状动脉计算机断层血管造影诊断为稳定型冠状动脉疾病（CAD）的患者，其中279例有钙化斑块（CP），153例有非钙化斑块（NCP），56例有混合斑块（MP）。对斑块周围PCAT的体积、脂肪衰减指数（FAI）以及第10百分位数、第90百分位数、中位数和最小亨氏单位（HU）值进行量化。比较不同斑块类型之间的临床特征和PCAT定量参数。
结果
在年龄、性别、体重指数、危险因素和斑块位置方面，未观察到组间差异。NCP组的长度和PCAT体积低于CP组和MP组（P < 0.001），而CP组和MP组之间无显著差异（P > 0.05）。NCP和MP患者的PCAT的FAI以及第10百分位数、第90百分位数、中位数和最小HU值高于CP患者（P < 0.001）；然而，这些值在NCP组和MP组之间无显著差异（P > 0.05）。
结论
作为CAD生物传感器的PCAT定量参数在不同斑块类型之间存在差异。
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