Abbas Alaa Ahmed, Abdulkader Hadil Adnan, Giordo Roberta, Ashour Hossam M, Erre Gian Luca, Pintus Gianfranco, Zayed Hatem
Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, 505055 Dubai, United Arab Emirates.
Int J Biol Macromol. 2023 Apr 30;235:123783. doi: 10.1016/j.ijbiomac.2023.123783. Epub 2023 Feb 22.
Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can play a role in the pathogenesis of several diseases. Rheumatic diseases are a varied group of autoimmune and inflammatory disorders affecting mainly the musculoskeletal system. Notably, circRNAs, which are essential immune system gene modulators, are strongly linked to the occurrence and progression of autoimmune disorders. Here, we present and discuss the current findings concerning the roles, implications and theragnostic potentials of circRNAs in common rheumatic diseases, including ankylosing spondylitis (AS), osteoarthritis (OA), osteoporosis (OP), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Crohn's disease (CD), and gout. This review aims to provide new insights to support the development of novel diagnostic and therapeutic strategies for these disabling diseases.
环状RNA（circRNA）是一类非编码RNA（ncRNA），是高度稳定且普遍存在的分子，具有组织特异性表达。越来越多的证据表明，circRNA的异常表达可在多种疾病的发病机制中发挥作用。风湿性疾病是一组多样的自身免疫性和炎症性疾病，主要影响肌肉骨骼系统。值得注意的是，circRNA作为重要的免疫系统基因调节剂，与自身免疫性疾病的发生和发展密切相关。在此，我们展示并讨论了目前关于circRNA在常见风湿性疾病中的作用、影响及诊疗潜力的研究结果，这些疾病包括强直性脊柱炎（AS）、骨关节炎（OA）、骨质疏松症（OP）、类风湿关节炎（RA）、系统性红斑狼疮（SLE）、克罗恩病（CD）和痛风。本综述旨在提供新的见解，以支持开发针对这些致残性疾病的新型诊断和治疗策略。
