Cheng Hsiang-Hung, Luo Mei, Jiang Jing-Rong, Wang Chun-Xia
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
Curr Pharm Biotechnol. 2025;26(3):319-327. doi: 10.2174/0113892010262829240214061103.
Rheumatoid arthritis (RA) is an autoimmune disease with no known cure that results in joint deformities and dysfunction, significantly impacting the quality of life of patients. The abnormal NF-κB signaling pathway in RA has emerged as a crucial research area for the development of RA therapies, with non-coding RNAs (ncRNAs) serving as a potentially meaningful avenue to regulate it. Thus, understanding the role of ncRNAs in RA and the identification of new therapeutic targets have become pressing issues in the field. In this review, we aim to summarize recent studies on ncRNAs that regulate the NF-κB signaling pathway in RA, including miRNAs, lncRNAs, and circRNAs, as well as the mechanisms by which drugs modulate NF-κB activity. By highlighting these recent advances, we hope to promote further research into targeted RA therapy and provide novel directions and ideas for researchers in the field.
类风湿性关节炎（RA）是一种无法治愈的自身免疫性疾病，会导致关节畸形和功能障碍，严重影响患者的生活质量。RA中异常的核因子κB（NF-κB）信号通路已成为RA治疗开发的关键研究领域，非编码RNA（ncRNAs）是调节该通路的一个潜在有意义的途径。因此，了解ncRNAs在RA中的作用以及确定新的治疗靶点已成为该领域的紧迫问题。在本综述中，我们旨在总结近期关于ncRNAs调节RA中NF-κB信号通路的研究，包括微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），以及药物调节NF-κB活性的机制。通过强调这些最新进展，我们希望促进对RA靶向治疗的进一步研究，并为该领域的研究人员提供新的方向和思路。
