Rheumatology Unit, University of Pisa, Pisa, Italy; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Section of Statistics, University of Pisa, Pisa, Italy.
Microvasc Res. 2023 Jul;148:104509. doi: 10.1016/j.mvr.2023.104509. Epub 2023 Feb 21.
To evaluate finger proximal-distal gradient (PDG) perfusion in subjects with primary Raynaud's phenomenon (PRP), then making comparisons with systemic sclerosis (SSc) patients and healthy controls (HC).
Consecutive adult PRP subjects were enrolled, along with an equal number of SSc and HC. Peripheral blood perfusion of the hands was assessed by laser speckle contrast analysis (LASCA). PDG was then calculated applying a generalizable formula independent of both intra- and inter-personal factors. Non-specific anti-nuclear autoantibody (ANA) isolated positivity was assessed.
Fifty PRP patients (88 % female, mean age 45 ± 17.9 years) were enrolled, along with 50 SSc patients and 50 HC. After adjusting mean PDG results for age and sex, no significant differences emerged between PRP and SSc (1.80 ± 0.43 vs 1.76 ± 0.53; p = 0.294). Conversely, PRP values were significantly reduced when compared to HC (2.72 ± 0.37; p < 0.001). Among PRP subjects, no significant differences were found regarding isolated ANA positivity (1.86 ± 0.44 vs 1.74 ± 0.44; p = 0.42).
PRP and SSc seems to share the same basal PDG perfusion impairment assessed by LASCA. Isolated ANA positivity, in the absence of clinical and capillaroscopic suspicion for secondary causes, should not be considered an exclusion criterion for PRP classification.
评估原发性雷诺现象（PRP）患者手指近-远梯度（PDG）灌注，并与系统性硬化症（SSc）患者和健康对照（HC）进行比较。
连续纳入成年 PRP 患者，以及数量相等的 SSc 患者和 HC。通过激光散斑对比分析（LASCA）评估手部外周血液灌注。然后应用一种独立于个体内和个体间因素的通用公式计算 PDG。评估非特异性抗核自身抗体（ANA）孤立阳性。
共纳入 50 例 PRP 患者（88%为女性，平均年龄 45±17.9 岁）、50 例 SSc 患者和 50 例 HC。在调整 PDG 均值以适应年龄和性别后，PRP 与 SSc 之间无显著差异（1.80±0.43 对 1.76±0.53；p=0.294）。然而，PRP 值与 HC 相比显著降低（2.72±0.37；p<0.001）。在 PRP 患者中，ANA 孤立阳性的比例无显著差异（1.86±0.44 对 1.74±0.44；p=0.42）。
LASCA 评估的 PRP 和 SSc 似乎具有相同的基础 PDG 灌注损伤。在没有临床和毛细血管镜检查怀疑继发性原因的情况下，ANA 孤立阳性不应作为 PRP 分类的排除标准。
