Red Glead Discovery, Lund, Sweden.
Department of Chemistry, Lund University, Lund, Sweden.
J Labelled Comp Radiopharm. 2023 Apr-May;66(4-6):138-144. doi: 10.1002/jlcr.4021. Epub 2023 Mar 2.
α-deuterated carboxylic acids have been synthesized from the corresponding malonic acids via hydrogen/deuterium exchange and decarboxylation in presence of D O. The method is general, mild and efficient and does not require organic solvents or other additives. Yields range between 83% and 94% and purification was not necessary. Starting materials were easy accessible and the α-deuterated carboxylic acids may easily be transformed to other labeled compounds such as alcohols, aldehydes, esters, and amides. Characterization with NMR confirmed purity and isotopic purity.
α-氘代羧酸已通过相应的丙二酸在 D2O 存在下的氢/氘交换和脱羧反应合成。该方法通用、温和且高效，不需要有机溶剂或其他添加剂。产率在 83%至 94%之间，无需进一步纯化。起始原料易得，α-氘代羧酸可轻松转化为其他标记化合物，如醇、醛、酯和酰胺。NMR 表征证实了产物的纯度和同位素纯度。
