通过光化学脱羧反应使游离羧酸发生轻度氘交换反应。
A mild deuterium exchange reaction of free carboxylic acids by photochemical decarboxylation.
机构信息
Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu 525-8577, Japan.
出版信息
Chem Commun (Camb). 2010 Sep 7;46(33):6177-9. doi: 10.1039/c0cc01464h. Epub 2010 Jul 26.
PMID:20657946
Abstract
Deuterium exchange of a carboxy group was achieved by photochemical decarboxylation of free carboxylic acids in the presence of thiol and a small amount of D(2)O, and a deuterated product with excellent deuterium content was obtained; this reaction is a practical means of synthesizing regioselective deuterium-labelled compounds under mild reaction conditions.
摘要
通过在硫醇和少量 D(2)O 的存在下进行光化学脱羧反应，实现了羧基的氘交换，得到了具有优异氘含量的氘代产物；该反应是在温和的反应条件下合成区域选择性氘标记化合物的实用方法。
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