Rodríguez Holguín Socorro, Folgueira-Ares Rocío, Crego Alberto, López-Caneda Eduardo, Corral Montserrat, Cadaveira Fernando, Doallo Sonia
Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
Psychological Neuroscience Laboratory (PNL), Research Center in Psychology (CIPsi), School of Psychology, University of Minho, Campus de Gualtar, Gualtar, Portugal.
Front Pharmacol. 2023 Feb 7;14:1034248. doi: 10.3389/fphar.2023.1034248. eCollection 2023.
Verbal memory may be affected by engagement in alcohol binge drinking during youth, according to the findings of neuropsychological studies. However, little is known about the dynamics of the neural activity underlying this cognitive process in young, heavy drinkers. To investigate brain event-related potentials associated with cued recall from episodic memory in binge drinkers and controls. Seventy first-year university students were classified as binge drinkers (32: 17 female) or controls (38: 18 female). The participants completed a verbal paired associates learning task during electroencephalogram (EEG) recording. ERPs elicited by old and new word pairs were extracted from the cued-recall phase of the task by using Principal Component Analysis. Subjects also performed a standardized neuropsychological verbal learning test. Two of the three event-related potentials components indicating old/new memory effects provided evidence for anomalies associated with binge drinking. The old/new effects were absent in the binge drinkers in the two subsequent posterior components, identified with the late parietal component and the late posterior negativity The late frontal component revealed similar old/new effects in both groups. Binge drinkers showed similar behavioural performance to controls in the verbal paired associates task, but performed poorly in the more demanding short-term cued-recall trial of a neuropsychological standardized test. Event-related potentials elicited during a verbal cued-recall task revealed differences in brain functioning between young binge drinkers and controls that may underlie emergent deficits in episodic memory linked to alcohol abuse. The brain activity of binge drinkers suggests alterations in the hippocampal - posterior parietal cortex circuitry subserving recognition and recollection of the cue context and generation of the solution, in relation to verbal information shallowly memorised.
神经心理学研究结果表明，青少年时期大量酗酒可能会影响言语记忆。然而，对于年轻酗酒者这一认知过程背后神经活动的动态变化，我们知之甚少。为了研究与情景记忆线索回忆相关的脑事件相关电位在酗酒者和对照组中的情况。70名大学一年级学生被分为酗酒者（32人：17名女性）或对照组（38人：18名女性）。参与者在脑电图（EEG）记录过程中完成了一项言语配对联想学习任务。通过主成分分析从任务的线索回忆阶段提取新旧单词对引发的事件相关电位。受试者还进行了一项标准化的神经心理学言语学习测试。表明新旧记忆效应的三个事件相关电位成分中的两个，为与酗酒相关的异常情况提供了证据。在随后的两个后部成分中，酗酒者没有出现新旧效应，这两个成分分别被确定为顶叶晚期成分和后部晚期负波。额叶晚期成分在两组中显示出相似的新旧效应。在言语配对联想任务中，酗酒者的行为表现与对照组相似，但在神经心理学标准化测试中要求更高的短期线索回忆试验中表现较差。言语线索回忆任务中引发的事件相关电位揭示了年轻酗酒者和对照组在大脑功能上的差异，这些差异可能是与酒精滥用相关的情景记忆新出现缺陷的基础。酗酒者的大脑活动表明，在与浅层记忆的言语信息相关的线索背景识别和回忆以及解决方案生成方面，海马体 - 顶叶后部皮质回路发生了改变。
