School of Medicine, Jiangsu University, Zhenjiang, China.
Department of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Pathol Oncol Res. 2023 Feb 7;29:1610931. doi: 10.3389/pore.2023.1610931. eCollection 2023.
Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis, progression, and prognosis. The E3 ubiquitin ligase is the crucial enzyme in the ubiquitination reaction and determines the specificity of ubiquitination substrates, and thus, the cellular effects. The HECT E3 ligases are the second largest E3 ubiquitin ligase family characterized by containing a HECT domain that has E3 ubiquitin ligase activity. The HECT E3 ubiquitin ligases have been found to engage in GC progression. However, whether HECT E3 ligases function as tumor promoters or tumor suppressors in GC remains controversial. In this review, we will focus on recent discoveries about the role of the HECT E3 ubiquitin ligases, especially members of the NEDD4 and other HECT E3 ligase subfamilies, in GC.
胃癌（GC）是最恶性的胃肠道肿瘤之一，发病率和死亡率极高。细胞信号蛋白的泛素化修饰已被证明在 GC 肿瘤发生、进展和预后中发挥重要作用。E3 泛素连接酶是泛素化反应中的关键酶，决定了泛素化底物的特异性，从而决定了细胞效应。HECT E3 连接酶是第二大 E3 泛素连接酶家族，其特征是含有具有 E3 泛素连接酶活性的 HECT 结构域。已经发现 HECT E3 泛素连接酶参与 GC 的进展。然而，HECT E3 连接酶在 GC 中是作为肿瘤促进剂还是肿瘤抑制剂仍存在争议。在这篇综述中，我们将重点介绍 HECT E3 泛素连接酶，特别是 NEDD4 及其它 HECT E3 连接酶亚家族成员，在 GC 中的最新发现。
