UMR 1253, iBrain, Université de Tours, Inserm, 37044 Tours, France.
CHRU de Tours, Service de Biochimie et Biologie Moléculaire, 37044 Tours, France.
Int J Mol Sci. 2022 Mar 31;23(7):3882. doi: 10.3390/ijms23073882.
The ubiquitin pathway regulates the function of many proteins and controls cellular protein homeostasis. In recent years, it has attracted great interest in neurodevelopmental and neurodegenerative diseases. Here, we have presented the first review on the roles of the 9 proteins of the HECT E3 ligase NEDD4 subfamily in the development and function of neurons in the central nervous system (CNS). We discussed their regulation and their direct or indirect involvement in neurodevelopmental diseases, such as intellectual disability, and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease or Amyotrophic Lateral Sclerosis. Further studies on the roles of these proteins, their regulation and their targets in neurons will certainly contribute to a better understanding of neuronal function and dysfunction, and will also provide interesting information for the development of therapeutics targeting them.
泛素途径调节许多蛋白质的功能，并控制细胞内蛋白质的动态平衡。近年来，它在神经发育和神经退行性疾病中引起了极大的兴趣。在这里，我们首次综述了 HECT E3 连接酶 NEDD4 亚家族的 9 种蛋白在中枢神经系统（CNS）神经元发育和功能中的作用。我们讨论了它们的调节及其直接或间接参与神经发育性疾病，如智力障碍，以及神经退行性疾病，如阿尔茨海默病、帕金森病或肌萎缩侧索硬化症。进一步研究这些蛋白在神经元中的作用、调节及其靶标，必将有助于更好地理解神经元的功能和功能障碍，也将为针对这些蛋白的治疗方法的开发提供有趣的信息。
