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基质金属蛋白酶分析及其在疾病中的作用。

Matrix metalloproteinase profiling and their roles in disease.

作者信息

Chang Mayland

机构信息

Department of Chemistry and Biochemistry, University of Notre Dame Notre Dame IN 46556 USA

出版信息

RSC Adv. 2023 Feb 21;13(9):6304-6316. doi: 10.1039/d2ra07005g. eCollection 2023 Feb 14.

DOI:10.1039/d2ra07005g
PMID:36825288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9942564/
Abstract

Matrix metalloproteinases (MMPs) play roles in remodelling of the extracellular matrix that occurs during morphogenesis, repair, and angiogenesis. Dysregulation of extracellular matrix remodelling can lead to cell proliferation, invasion, and tissue fibrosis. Identification of a specific MMP(s) in a disease has been challenging due to the presence of 24 closely-related human MMPs, each existing in three forms, of which only one is active and capable of catalysis. This review focuses on methods for MMP profiling, with particular emphasis on the batimastat affinity resin that binds only to the active forms of MMPs and related ADAMs (a disintegrin and metalloproteinases), which are then identified by mass spectrometry. Use of the batimastat affinity resin has identified targets for intervention in several human diseases.

摘要

基质金属蛋白酶（MMPs）在形态发生、修复和血管生成过程中发生的细胞外基质重塑中发挥作用。细胞外基质重塑失调可导致细胞增殖、侵袭和组织纤维化。由于存在24种密切相关的人类MMPs，每种MMPs以三种形式存在，其中只有一种具有活性并能够催化，因此在疾病中鉴定特定的MMPs具有挑战性。本综述重点介绍MMPs分析方法，特别强调仅与MMPs的活性形式以及相关的ADAMs（一种解整合素和金属蛋白酶）结合的batimastat亲和树脂，然后通过质谱法进行鉴定。batimastat亲和树脂的使用已经确定了几种人类疾病的干预靶点。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ec/9942564/2743a2d451b8/d2ra07005g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ec/9942564/8adad0e908e5/d2ra07005g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ec/9942564/ff1e06a0bfc9/d2ra07005g-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ec/9942564/bcbdb45448ce/d2ra07005g-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ec/9942564/32a844b41d05/d2ra07005g-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ec/9942564/7445b30a5ef9/d2ra07005g-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ec/9942564/0c8a5ba0520a/d2ra07005g-f11.jpg
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