Potapova G N, Sokolova R I, Arabidze G G, Kazeev K N, Kazanchian P O
Kardiologiia. 1987 Aug;27(8):13-8.
Renal parenchyma, and the juxtaglomerular apparatus in particular, was studied in 23 patients with verified diagnosis of pheochromocytoma. Intraoperative renal biopsy was performed in 21 cases, and kidneys obtained at nephrectomy or autopsy were examined in 2 cases. Twenty-one patients were examined following the removal of pheochromocytoma (2 patients died). Arterial BP returned to normal in 86.4%, and residual hypertension due to continuous hyperfunction of the juxtaglomerular apparatus in the presence of hypertensive angiosclerosis was recorded in 13.6%. Tubular epithelial atrophy of varying markedness, associated with renal ischemia, was detected in all cases. The pathogenetic contribution of the renin-angiotensin system to pre- and postoperative hypertension in pheochromocytoma patients is discussed.
对23例经确诊的嗜铬细胞瘤患者的肾实质，尤其是肾小球旁器进行了研究。21例患者进行了术中肾活检，2例患者的肾脏取自肾切除术或尸检。21例患者在切除嗜铬细胞瘤后接受了检查（2例患者死亡）。86.4%的患者动脉血压恢复正常，13.6%的患者因存在高血压性血管硬化，肾小球旁器持续功能亢进导致残留高血压。在所有病例中均检测到与肾缺血相关的不同程度的肾小管上皮萎缩。本文讨论了肾素-血管紧张素系统对嗜铬细胞瘤患者术前和术后高血压的发病机制作用。
