可见光响应性硒纳米颗粒联合声动力疗法促进伤口愈合
Visible Light-Responsive Selenium Nanoparticles Combined with Sonodynamic Therapy to Promote Wound Healing.
作者信息
Huang Wenjing, Hu Binbin, Yuan Yalin, Fang Huaqiang, Jiang Junkai, Li Qun, Zhuo Yi, Yang Xuetao, Wei Jinlu, Wang Xiaolei
机构信息
The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi330088, P. R. China.
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi330088, P. R. China.
出版信息
ACS Biomater Sci Eng. 2023 Mar 13;9(3):1341-1351. doi: 10.1021/acsbiomaterials.2c01119. Epub 2023 Feb 24.
In this paper, we synthesized selenium nanoparticles (SeNPs) that could be effectively excited by pure yellow light (YL) source to enhance antibacterial ability. Meanwhile, YL could also play the role of anti-inflammatory and promote wound healing. In addition, in order to overcome the problem of low penetration depth of photodynamic therapy (PDT), SeNPs were encapsulated with polyethylenimine (PEI), then modified with the sound sensitive agent indocyanine green (ICG), realizing the combined photoacoustic therapy to promote the healing of wounds infected by drug-resistant bacteria. The antibacterial efficiency of methicillin-resistant (MRSA) and () reached more than 99% in and experiments within 10 min, which could safely and quickly kill drug-resistant bacteria to repair and heal wounds.
在本文中，我们合成了能够被纯黄色光源有效激发以增强抗菌能力的硒纳米颗粒（SeNPs）。同时，黄色光还能起到抗炎作用并促进伤口愈合。此外，为了克服光动力疗法（PDT）穿透深度低的问题，用聚乙烯亚胺（PEI）包裹SeNPs，然后用声敏剂吲哚菁绿（ICG）进行修饰，实现联合光声疗法以促进耐药菌感染伤口的愈合。在 和 实验中，耐甲氧西林金黄色葡萄球菌（MRSA）和（此处原文缺失部分内容）的抗菌效率在10分钟内达到99%以上，能够安全快速地杀灭耐药菌以修复和愈合伤口。
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