Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti-neuroinflammatory Activity from a Species.

Sarglamides A-E (-), representing the first example of heterodimers of a --cinnamoylindolidinoid and α-phelladrene derivatives, were isolated from subsp. . Particularly, compounds and possess unprecedented cagelike 6/6/5/6/5- and 6/6/6/6/5-fused pentacyclic scaffolds, respectively. Their structures were established by spectroscopic analysis, X-ray crystallography, quantum-chemical calculations, and chemical conversions. Plausible biosynthetic pathways of - involving the coisolated enantiomers and were proposed. Compounds - showed inhibitory activity against lipopolysaccharide-induced inflammation in BV-2 microglial cells.