Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, PR China.
Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang, PR China.
Nat Prod Res. 2023 Mar;37(6):882-890. doi: 10.1080/14786419.2022.2095633. Epub 2022 Jul 7.
Hupelactones A () and B (), two new eudesmanolide-type enantiomers of the corresponding compounds, along with four mono- (-) and nine dimeric- (-) known sesquiterpenoids were isolated from the whole plant of var. . The new structures including the absolute configurations were determined by comparison with previously reported enantiomers, extensive spectroscopic methods in combination with electronic circular dichroism (ECD) calculations. All the isolates were evaluated for their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine BV-2 microglial cells. Among them, the dimeric lindenane sesquiterpenoids shizukaols F () and G () exhibited the most potent activities, with IC values of 2.65 and 4.60 μM, respectively.
胡薄荷酮 A () 和 B (), 两种新型的对应化合物的桉烷型对映异构体，以及从 var. 的全植物中分离出的四个单萜 (-) 和九个倍半萜二聚体 (-)。新结构包括绝对构型是通过与以前报道的对映异构体的比较，结合电子圆二色性 (ECD) 计算的广泛光谱方法确定的。所有分离物均评估了其对脂多糖 (LPS) 诱导的小鼠 BV-2 小胶质细胞中一氧化氮 (NO) 产生的抑制活性。其中，二聚的里那醇型倍半萜类化合物 shizukaols F () 和 G () 表现出最强的活性，IC 值分别为 2.65 和 4.60 μM。
