Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Yunnan Key Laboratory of Pharmacology for Natural Products, School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China.
Curr Oncol. 2023 Feb 1;30(2):1784-1793. doi: 10.3390/curroncol30020138.
To explore the clinicopathological features of solitary fibrous tumors (SFTs) of the lung.
We collected the clinical data of 52 patients with SFTs of the lung confirmed by pathology, and summarized the clinical, radiological, and morphological features, the immunophenotypes, and the prognosis of SFTs.
Fifty-two cases of SFTs of the lung were enrolled in this study, including 51 cases of borderline and 1 case of malignancy, 22 males and 30 females. The average onset age was 52.7 years. The lower lobe of the left lung was the preferred site of SFTs, accounting for 30.77% (16/52). Chest CT showed regular and well-demarcated soft tissue density mass, and the tumor size of most cases (46/52, 88.46%) was 1-10 cm. Morphological features: The distribution of tumor cells showed sparse and dense areas. Tumor cells were spindle-shaped, in whorls or hemangiopericytoma-like conformation. Atypia, mitotic figures, and necrosis were found. Immunohistochemistry showed positive expression of CD34, STAT6, Vimentin, BCL2, and CD99. Ki-67 was ≤ 5% in borderline SFTs and >20% in a malignant SFT.
Solitary fibrous tumors of the lung occur more frequently in middle-aged and elderly people, and there is no significant difference in gender. The lower lobe of the left lung is the preferred site of SFTs. The size of most SFTs is 1-10 cm. Chest CT shows morphologically regular and well-demarcated soft tissue density mass. Pathologically, SFTs of the lung are mostly borderline and occasionally malignant. Immunohistochemistry shows the positive expression of CD34, STAT6, Vimentin, BCL2, and CD99.
探讨肺孤立性纤维瘤（SFT）的临床病理特征。
我们收集了 52 例经病理证实的肺 SFT 患者的临床资料，总结了 SFT 的临床、影像学和形态学特征、免疫表型和预后。
本研究共纳入 52 例肺 SFT 患者，其中交界性 51 例，恶性 1 例，男 22 例，女 30 例。平均发病年龄为 52.7 岁。左肺下叶是 SFT 的首选部位，占 30.77%（16/52）。胸部 CT 显示规则、边界清楚的软组织密度肿块，大多数病例（46/52，88.46%）肿瘤大小为 1-10cm。形态学特征：肿瘤细胞分布呈稀疏区和密集区。肿瘤细胞呈梭形，呈漩涡状或呈血管外皮细胞瘤样排列。有异型性、有丝分裂象和坏死。免疫组化显示 CD34、STAT6、波形蛋白、BCL2 和 CD99 阳性表达。交界性 SFT 的 Ki-67 为≤5%，恶性 SFT 的 Ki-67 为>20%。
肺孤立性纤维瘤多见于中老年人，性别无明显差异。左肺下叶是 SFT 的首选部位。大多数 SFT 的大小为 1-10cm。胸部 CT 显示形态规则、边界清楚的软组织密度肿块。肺 SFT 多为交界性，偶有恶性。免疫组化显示 CD34、STAT6、波形蛋白、BCL2 和 CD99 阳性表达。
