Clinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Shoosh Square, Fadaeiyan Eslam Street, Shishehgar Khaneh Street, Tehran, Iran.
Int Urogynecol J. 2023 Aug;34(8):1955-1960. doi: 10.1007/s00192-023-05486-5. Epub 2023 Feb 24.
Conflicting results have been reported on the effect of vitamin D supplementation on urinary incontinence (UI). Therefore, the aim of this study was to evaluate the effect of consuming vitamin D oral supplements on improving urge UI (UUI) in postmenopausal women with vitamin D deficiency.
This randomized clinical trial was conducted in 2019-2020 in postmenopausal women with UUI or nocturia more than once at night with vitamin D levels less than 30 ng/ml. After recording the severity of UI and its impact on the patient's daily life, patients were randomly divided into two groups of 45 patients: one taking vitamin D (50,000 IU) tablets and one taking placebo weekly for 8 weeks.
There was no significant difference between the two groups in terms of the severity of UI and the frequency of nocturia before treatment. However, after treatment, in the vitamin D group, the severity of UI and the frequency of nocturia significantly reduced. Before treatment, the impact of UI on patients' daily life was reported to be high in more than 70% of patients in both groups, which was not significantly different; however, after treatment, its impact was significantly reduced in the vitamin D group.
The findings of the present study showed that in postmenopausal women with UUI or nocturia, weekly use of vitamin D 50,000 IU tablets for 8 weeks can reduce the severity of UI and the frequency of nocturia, and reduce their impact on disruption in daily life.
关于维生素 D 补充对尿失禁（UI）的影响，已有相互矛盾的结果报告。因此，本研究旨在评估口服维生素 D 补充剂对改善绝经后维生素 D 缺乏症妇女的急迫性 UI（UUI）的作用。
这是一项 2019-2020 年在 UUI 或每晚夜尿超过一次且维生素 D 水平低于 30ng/ml 的绝经后妇女中进行的随机临床试验。记录 UI 的严重程度及其对患者日常生活的影响后，将患者随机分为两组，每组 45 例：一组服用维生素 D（50000IU）片剂，一组每周服用安慰剂 8 周。
两组治疗前 UI 严重程度和夜尿次数无显著差异。然而，治疗后，维生素 D 组 UI 严重程度和夜尿次数明显降低。治疗前，两组均有超过 70%的患者报告 UI 对其日常生活的影响较高，差异无统计学意义；然而，治疗后，维生素 D 组的影响明显降低。
本研究结果表明，对于 UUI 或夜尿症的绝经后妇女，每周服用维生素 D 50000IU 片剂 8 周可降低 UI 严重程度和夜尿次数，并降低其对日常生活干扰的影响。
